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. 1985 Mar 18;77(2):229-35.
doi: 10.1016/0022-1759(85)90035-3.

Carboxyethyl gamma-aminobutyric acid, a polyamine derivative molecule with a growth effect on hybridomas

A Cerino, M De Amici, F F Fussi, G C Astaldi Ricotti

Carboxyethyl gamma-aminobutyric acid, a polyamine derivative molecule with a growth effect on hybridomas

A Cerino et al. J Immunol Methods. .

Abstract

An increased proliferation of hybridomas is induced by a polyamine derivative molecule, CEGABA (carboxyethyl gamma-aminobutyric acid). The effects of CEGABA and CR-ECGS (endothelial cell growth supplement) on hybridoma growth are similar. However, both factors are less efficient than HECS (human endothelial culture supernatant) in inducing hybridoma growth through all the steps of hybridoma production, including: recovery after fusion, cloning, and proliferation.

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