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. 2024 Oct 21;10(1):247-251.
doi: 10.1016/j.ekir.2024.10.012. eCollection 2025 Jan.

De novo Membranous Nephropathy in Renal Allografts is Associated With Protocadherin FAT1

Laith F Al-Rabadi  1 , Aaron Storey  2 , Christopher P Larsen  2 , Samar I Hassen  2 , Monica Patricia Revelo  3 , Ravi Shankar Singh  3 , Eszter Lazar-Molnar  3 , Dharmendra Jain  3 , Abdelrahman Ibrahim  1 , Frank Darras  4 , Rania Salam  5 , Ala Al-Rabadi  6 , Naruemon Wikan  1 , Vanessa Redecke  3 , Manish Talwar  7 , Hans Haecker  3 , Laurence H Beck Jr  8 , Tiffany N Caza  2
Affiliations

De novo Membranous Nephropathy in Renal Allografts is Associated With Protocadherin FAT1

Laith F Al-Rabadi et al. Kidney Int Rep. .
No abstract available

Keywords: FAT1; de novo membranous nephropathy; donor-specific antibodies; kidney biopsy.

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Figures

Figure 1
Figure 1
Histopathology of the membranous nephropathy component of a typical case of FAT1-positive DNMN. (a) PAS stain demonstrating mesangial matrix expansion and prominent capillary loops, scale bar = 20 μm; (b) immunofluorescence for IgG showing an incomplete global granular capillary loop pattern of staining, scale bar = 20 μm; (c) immunofluorescence for C3 is of lower intensity, scale bar = 20 μm; (d) ultrastructural photomicrograph showing stage I to II subepithelial electron dense immune type deposits, magnification 5000x; (e) ultrastructural photomicrograph showing mesangial electron dense deposits, magnification 12000×; and (f) positive immunofluorescence for FAT1, scale bar = 20 μm. DNMN, de novo membranous nephropathy; PAS, periodic acid-Schiff.
See this image and copyright information in PMC

References

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