Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 May;15(5):561-564.
doi: 10.1002/alr.23533. Epub 2025 Jan 15.

Preclinical Therapeutic Efficacy of the Ciprofloxacin Azithromycin Sinus Stent for Pseudomonas aeruginosa Sinusitis

Adam J Skelton  1 , Dong-Jin Lim  1 , Brenton T Bicknell  1 , Daniel Skinner  1 , Shaoyan Zhang  1 , Bradford A Woodworth  1   2 , Do-Yeon Cho  1   2   3
Affiliations

Preclinical Therapeutic Efficacy of the Ciprofloxacin Azithromycin Sinus Stent for Pseudomonas aeruginosa Sinusitis

Adam J Skelton et al. Int Forum Allergy Rhinol. 2025 May.
No abstract available

Keywords: antibiotic‐eluting sinus stent; azithromycin; chronic rhinosinusitis; chronic sinusitis; ciprofloxacin; sinusitis; topical delivery.

PubMed Disclaimer

Figures

FIGURE 1
FIGURE 1
Computed tomography and heterophils counts. (A) Representative CT images over the course of the study at Week 0, 1, and 3. (B) CT scores at Week 3: The CASS group had a statistically significant lower CT score (% of opacification) compared to the Sham group (* p < 0.05). C. Heterophil counts over the course of the study: Counts were significantly elevated in all rabbits at week 1 compared to baseline (**<0.01). With the restoration of mucociliary clearance, heterophil counts were decreased by week 3 without a significant difference between the two groups (p > 0.05).
FIGURE 2
FIGURE 2
Histopathology findings at Week 3. (A) H&E staining of maxillary sinus (inferior) with non‐drug eluting (Sham) stent. (B) H&E staining of maxillary sinus (Inferior) with CASS stent. (C) Representative image of counting inflammatory cells using a hybrid cell counter software (BZ‐X800 Analyzer (Keyence, Japan). (D) The height of the epithelial cell layer: There was no difference in epithelial heights between those rabbits treated either with non‐drug eluting (Sham) or CASS. (E) The height of the subepithelial layer: The heights of the subepithelial layer were significantly higher in those rabbits treated with non‐drug eluting (Sham) stents compared to those treated with CASS (** p < 0.01). (F) Heterophil counts in the subepithelial layer between Sham and CASS: Heterophil counts were significantly higher in the Sham than in the CASS (** p < 0.01).
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Costerton J. W., Stewart P. S., and Greenberg E. P., “Bacterial Biofilms: A Common Cause of Persistent Infections,” Science 284 (1999): 1318–1322. - PubMed
    1. Hariri B. M. and Cohen N. A., “New Insights Into Upper Airway Innate Immunity,” American Journal of Rhinology & Allergy 30 (2016): 319–323. - PMC - PubMed
    1. Lim D. J., Bicknell B. T., Rivers N., et al., “Safety and Pharmacokinetics of a Ciprofloxacin and Azithromycin Stent for Chronic Rhinosinusitis,” The Laryngoscope 134, no. 9 (2024): 3953–3959. - PMC - PubMed
    1. Lim D. J., Skinner D., McLemore J., et al., “In‐vitro Evaluation of a Ciprofloxacin and Azithromycin Sinus Stent for Pseudomonas aeruginosa Biofilms,” International Forum of Allergy & Rhinology 10 (2020): 121–127. - PMC - PubMed
    1. Lim D. J., McCormick J., Skinner D., et al., “Controlled Delivery of Ciprofloxacin and Ivacaftor via Sinus Stent in a Preclinical Model of Pseudomonas Sinusitis,” International Forum of Allergy & Rhinology 10 (2020): 481–488. - PMC - PubMed

LinkOut - more resources