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Review
. 2025 Jan 15;25(1):38.
doi: 10.1007/s10238-024-01554-2.

Mast cell-mediated microRNA functioning in immune regulation and disease pathophysiology

Qiuping Deng #  1 , Xiuju Yao #  2 , Siyun Fang  1 , Yueshan Sun  3 , Lei Liu  3 , Chao Li  1 , Guangquan Li  2 , Yuanbiao Guo  4 , Jinbo Liu  5
Affiliations
Review

Mast cell-mediated microRNA functioning in immune regulation and disease pathophysiology

Qiuping Deng et al. Clin Exp Med. .

Abstract

Upon stimulation and activation, mast cells (MCs) release soluble mediators, including histamine, proteases, and cytokines. These mediators are often stored within cytoplasmic granules in MCs and may be released in a granulated form. The secretion of cytokines and chemokines occurs within hours following activation, with the potential to result in chronic inflammation. In addition to their role in allergic inflammation, MCs are components of the tumor microenvironment (TME). MicroRNAs (miRNAs) are small RNA molecules that do not encode proteins, but regulate post-transcriptional gene expression by binding to the 3' non-coding regions of mRNAs. This plays a crucial role in the function of MC, including the key processes of MC proliferation, maturation, apoptosis, and activation. It has been demonstrated that miRNAs are also present in extracellular vesicles (EVs) secreted by MCs. EVs derived from MCs mediate intercellular communication by carrying miRNAs, affecting various diseases including allergic diseases, intestinal disorders, neuroinflammation, and tumors. These findings provide important insights into the therapeutic mechanisms and targets of miRNAs in MCs that affect diseases. This review discusses the relevance of miRNA production by MCs in regulating their own activity and the effect of miRNAs putatively produced by other cells in the control of MC activity and their participation in selected pathologies.

Keywords: Disease; EVs; Immune regulation; Mast cell; MicroRNA.

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Conflict of interest statement

Declarations. Conflict of Interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
miRNAs regulate the biological functions of MCs
Fig. 2
Fig. 2
Relationship between miRNAs of MCs and diseases
See this image and copyright information in PMC

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References

    1. Brzezińska-Błaszczyk E, Bąbolewska E. Stem cell factor-dependent mast cell proliferation maturation and activity can be regulated by inhibitory receptors. Cent Eur J nbsp Immunol. 2013;38(1):134–40.
    1. Elsaiey A, Mahmoud HS, Jensen CT, et al. Mastocytosis-a review of disease spectrum with imaging correlation. Cancers. 2021;13(20):5102. - PMC - PubMed
    1. Galli SJ, Borregaard N, Wynn TA. Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat Immunol. 2011;12(11):1035–44. - PMC - PubMed
    1. O’Mahony L, Akdis M, Akdis CA. Regulation of the immune response and inflammation by histamine and histamine receptors. J Allergy Clin Immunol. 2011;128(6):1153–62. - PubMed
    1. Makeyev EV, Maniatis T. Multilevel regulation of gene expression by microRNAs. Science. 2008;319(5871):1789–90. - PMC - PubMed

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