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Comment
. 2025 Jan 14;58(1):10-12.
doi: 10.1016/j.immuni.2024.11.022.

Gut know-how: IL-22 from T cells boosts stress resilience

Ruodi Yang  1 , Danyang He  2
Affiliations
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Gut know-how: IL-22 from T cells boosts stress resilience

Ruodi Yang et al. Immunity. .

Abstract

Immune activation during sustained stress typically worsens stress-related psychopathology. Whether it can enhance stress resilience remains unclear. In this issue of Immunity, Xia, Lu, Lan et al.1 uncover an anxiolytic function of intestinal IL-22 pathway, which protects against psychological stress.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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