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Comment
. 2025 Jan 14;58(1):12-14.
doi: 10.1016/j.immuni.2024.12.010.

Restimulation by macrophages exhausts T cells

Fernando Fernández-García  1 , Barbara B Maier  2
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Comment

Restimulation by macrophages exhausts T cells

Fernando Fernández-García et al. Immunity. .

Abstract

Inhibiting T cell exhaustion is an attractive cancer immunotherapy strategy. In this issue of Immunity, Waibl Polania et al. examine the microenvironmental signals regulating terminal T cell exhaustion and find that antigen presentation by tumor-associated macrophages, not tumor cells, drives terminal T cell exhaustion in glioblastoma.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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