Interleukin-17 and fat: Timing is everything

Matthew C Sinton¹, Olivia Shorthouse², Alice Costain², Juan F Quintana³

Affiliations

¹ Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK; Division of Immunology, Immunity to Infection and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK. Electronic address: matthew.sinton@manchester.ac.uk.
² Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK; Division of Immunology, Immunity to Infection and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
³ Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK; Division of Immunology, Immunity to Infection and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; Geoffrey Jefferson Brain Research Centre, University of Manchester, Manchester, UK. Electronic address: juan.quintana@manchester.ac.uk.

PMID: 39813991
DOI: 10.1016/j.immuni.2024.12.005

Comment

Interleukin-17 and fat: Timing is everything

Matthew C Sinton et al. Immunity. 2025.

. 2025 Jan 14;58(1):15-17.

doi: 10.1016/j.immuni.2024.12.005.

Authors

Matthew C Sinton¹, Olivia Shorthouse², Alice Costain², Juan F Quintana³

Affiliations

¹ Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK; Division of Immunology, Immunity to Infection and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK. Electronic address: matthew.sinton@manchester.ac.uk.
² Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK; Division of Immunology, Immunity to Infection and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
³ Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK; Division of Immunology, Immunity to Infection and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; Geoffrey Jefferson Brain Research Centre, University of Manchester, Manchester, UK. Electronic address: juan.quintana@manchester.ac.uk.

PMID: 39813991
DOI: 10.1016/j.immuni.2024.12.005

Abstract

Interleukin-17 plays a major role in controlling adipose tissue homeostasis. In a recent study published in Nature, Douglas et al. demonstrate that time-of-day-dependent expression of interleukin-17 by tissue-resident innate lymphocytes in the adipose tissue drives circadian regulation of adipose tissue homeostasis and function.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

Interleukin-17 as a key player in neuroimmunometabolism.
Douglas A, Stevens B, Lynch L. Douglas A, et al. Nat Metab. 2023 Jul;5(7):1088-1100. doi: 10.1038/s42255-023-00846-3. Epub 2023 Jul 20. Nat Metab. 2023. PMID: 37488456 Free PMC article. Review.

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Interleukin-17 and fat: Timing is everything

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Interleukin-17 and fat: Timing is everything

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