Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2025 Jan 14;58(1):8-10.
doi: 10.1016/j.immuni.2024.12.001.

IgG sialylation puts lung inflammation to REST

Lukasz Kedzierski  1 , Katherine Kedzierska  2
Affiliations
Free article
Comment

IgG sialylation puts lung inflammation to REST

Lukasz Kedzierski et al. Immunity. .
Free article

Abstract

The mechanisms underpinning susceptibility to influenza virus infection, resulting in life-threatening disease, are not well understood. In this issue of Immunity, Chakraborty et al. demonstrate that sialylated IgG suppresses NF-κB-driven inflammatory responses in the lungs by inducing repressor element-1 silencing transcription factor (REST) to prevent excessive inflammation without impacting viral replication.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

LinkOut - more resources