PROTACs in the treatment of viral diseases

doi:10.1080/17568919.2025.2453418

Editorial

. 2025 Feb;17(3):267-269.

doi: 10.1080/17568919.2025.2453418. Epub 2025 Jan 15.

PROTACs in the treatment of viral diseases

Ritesh P Bhole^{1

2}, Payal Kute³, Shilendra S Gurav⁴

Affiliations

¹ Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, India.
² Dr. D. Y. Patil Vidyapeeth, Dr. D. Y. Patil Dental College Hospital and Research Centre, Pimpri, India.
³ SSR College of Pharmacy, Silvassa, India.
⁴ Department of Pharmacognosy, Goa College of Pharmacy, Goa University, Panaji, India.

PMID: 39814466
PMCID: PMC11792865 (available on 2026-01-15)
DOI: 10.1080/17568919.2025.2453418

Editorial

PROTACs in the treatment of viral diseases

Ritesh P Bhole et al. Future Med Chem. 2025 Feb.

. 2025 Feb;17(3):267-269.

doi: 10.1080/17568919.2025.2453418. Epub 2025 Jan 15.

Authors

Ritesh P Bhole^{1

2}, Payal Kute³, Shilendra S Gurav⁴

Affiliations

¹ Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, India.
² Dr. D. Y. Patil Vidyapeeth, Dr. D. Y. Patil Dental College Hospital and Research Centre, Pimpri, India.
³ SSR College of Pharmacy, Silvassa, India.
⁴ Department of Pharmacognosy, Goa College of Pharmacy, Goa University, Panaji, India.

PMID: 39814466
PMCID: PMC11792865 (available on 2026-01-15)
DOI: 10.1080/17568919.2025.2453418

No abstract available

Keywords: Antiviral therapy; Drug resistance; Indomethacin-based PROTACs; PROTACs; PROTACs in clinical trials; Ubiquitin-proteasome system; Undruggable targets; Viral diseases.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Cited by

Key advances and application prospects of PROTAC technologies in the next 5 years.
Qin S, Xiao X. Qin S, et al. Future Med Chem. 2025 May;17(9):987-989. doi: 10.1080/17568919.2025.2498875. Epub 2025 May 2. Future Med Chem. 2025. PMID: 40314207 No abstract available.
Conquering PROTAC molecular design and drugability.
Bhole RP, Labhade S, Gurav SS. Bhole RP, et al. Bioanalysis. 2025 Apr;17(7):455-470. doi: 10.1080/17576180.2025.2481021. Epub 2025 Mar 20. Bioanalysis. 2025. PMID: 40114295 Review.

References

1. Bhole RP, Patil S, Kapare HS, et al. PROTAC beyond cancer-exploring the new therapeutic potential of proteolysis targeting chimeras. Curr Top Med Chem. 2024. Sep;24(23):2050–2073. - PubMed
1. Fauci AS, Lane HC, Redfield RR.. Covid-19—navigating the uncharted. N Engl J Med. 2020. Mar 26;382(13):1268–1269. - PMC - PubMed
1. Sun X, Gao H, Yang Y, et al. Protacs: great opportunities for academia and industry. Signal Transduct Target Ther. 2019. Dec 24;4(1):64. - PMC - PubMed
1. Bhole RP, Kute PR, Chikhale RV, et al. Unlocking the potential of PROTACs: a comprehensive review of protein degradation strategies in disease therapy. Bioorg Chem. 2023. Oct 1;139:106720. - PubMed
1. Xue Y, Bolinger AA, Zhou J. Novel approaches to targeted protein degradation technologies in drug discovery. Expert Opin Drug Discov. 2023. Apr 3;18(4):467–483. - PMC - PubMed

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[1] Bhole RP, Patil S, Kapare HS, et al. PROTAC beyond cancer-exploring the new therapeutic potential of proteolysis targeting chimeras. Curr Top Med Chem. 2024. Sep;24(23):2050–2073. - PubMed

[2] Bhole RP, Patil S, Kapare HS, et al. PROTAC beyond cancer-exploring the new therapeutic potential of proteolysis targeting chimeras. Curr Top Med Chem. 2024. Sep;24(23):2050–2073. - PubMed

[3] Fauci AS, Lane HC, Redfield RR.. Covid-19—navigating the uncharted. N Engl J Med. 2020. Mar 26;382(13):1268–1269. - PMC - PubMed

[4] Fauci AS, Lane HC, Redfield RR.. Covid-19—navigating the uncharted. N Engl J Med. 2020. Mar 26;382(13):1268–1269. - PMC - PubMed

[5] Sun X, Gao H, Yang Y, et al. Protacs: great opportunities for academia and industry. Signal Transduct Target Ther. 2019. Dec 24;4(1):64. - PMC - PubMed

[6] Sun X, Gao H, Yang Y, et al. Protacs: great opportunities for academia and industry. Signal Transduct Target Ther. 2019. Dec 24;4(1):64. - PMC - PubMed

[7] Bhole RP, Kute PR, Chikhale RV, et al. Unlocking the potential of PROTACs: a comprehensive review of protein degradation strategies in disease therapy. Bioorg Chem. 2023. Oct 1;139:106720. - PubMed

[8] Bhole RP, Kute PR, Chikhale RV, et al. Unlocking the potential of PROTACs: a comprehensive review of protein degradation strategies in disease therapy. Bioorg Chem. 2023. Oct 1;139:106720. - PubMed

[9] Xue Y, Bolinger AA, Zhou J. Novel approaches to targeted protein degradation technologies in drug discovery. Expert Opin Drug Discov. 2023. Apr 3;18(4):467–483. - PMC - PubMed

[10] Xue Y, Bolinger AA, Zhou J. Novel approaches to targeted protein degradation technologies in drug discovery. Expert Opin Drug Discov. 2023. Apr 3;18(4):467–483. - PMC - PubMed

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PROTACs in the treatment of viral diseases

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PROTACs in the treatment of viral diseases

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