Targeting the EZH2-SLFN11 pathway-a lesson in developing molecularly-informed treatments for recurrent small cell lung cancer
- PMID: 39816547
- PMCID: PMC11730446
- DOI: 10.21037/tcr-24-1755
Targeting the EZH2-SLFN11 pathway-a lesson in developing molecularly-informed treatments for recurrent small cell lung cancer
Keywords: Schlafen family member 11 (SLFN11); Small cell lung cancer (SCLC); enhancer of zeste homolog 2 (EZH2); irinotecan.
Conflict of interest statement
Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://tcr.amegroups.com/article/view/10.21037/tcr-24-1755/coif). F.S. has participated in an advisory board for OncoHost and received honoraria from MJH Life Sciences. M.S.D. has received honoraria from Plexus Communications, IDEO Health, Springer, Medical Educator Consortium, Dedham Group, DAVA Oncology, MJH Life Sciences, Targeted Oncology, OncLive, Association of Northern California Oncologists, Aptitude Health, MashUp Media, Curio Science, Med Learning Group, Triptych Health, and American Cancer Society; has participated in an advisory board for Advarra; has served as a consultant for Sanofi/Genzyme, Regeneron, Catalyst Pharmaceuticals, Novocure, Guardant, EMD Soreno, Janssen, Abbvie, Gilead, Daiichi Sankyo, and Bristol Myers Squibb; and has received institutional research funding from Merck, Genentech, CellSight, Novartis, and Varian. The authors have no other conflicts of interest to declare.
Comment on
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A Phase I/II Study of Valemetostat (DS-3201b), an EZH1/2 Inhibitor, in Combination with Irinotecan in Patients with Recurrent Small-Cell Lung Cancer.Clin Cancer Res. 2024 Sep 3;30(17):3697-3703. doi: 10.1158/1078-0432.CCR-23-3383. Clin Cancer Res. 2024. PMID: 38940666 Free PMC article. Clinical Trial.
References
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- NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Small Cell Lung Cancer V.2.2025. National Comprehensive Cancer Network, Inc. 2024. - PubMed
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