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Editorial
. 2025 Jan 15;17(1):100713.
doi: 10.4251/wjgo.v17.i1.100713.

Exosomes as promising frontier approaches in future cancer therapy

Fatt-Yang Chew  1   2 , Chin-Hung Tsai  3   4   5 , Kuang-Hsi Chang  6   7   8 , Yu-Kang Chang  5   6   9 , Ruey-Hwang Chou  10   11   12 , Yi-Jui Liu  13
Affiliations
Editorial

Exosomes as promising frontier approaches in future cancer therapy

Fatt-Yang Chew et al. World J Gastrointest Oncol. .

Abstract

In this editorial, we will discuss the article by Tang et al published in the recent issue of the World Journal of Gastrointestinal Oncology. They explored an innovative approach to enhancing gemcitabine (GEM) delivery and efficacy using human bone marrow mesenchymal stem cells (HU-BMSCs)-derived exosomes. The manufacture of GEM-loaded HU-BMSCs-derived exosomes (Exo-GEM) has been optimized. The Tang et al's study demonstrated that Exo-GEM exhibits enhanced cytotoxicity and apoptosis-inducing effects compared to free GEM, highlighting the potential of exosome-based drug delivery systems as a more effective and targeted approach to chemotherapy in pancreatic cancer. Additional in vivo studies are required to confirm the safety and effectiveness of Exo-GEM before it can be considered for clinical use.

Keywords: Apoptosis; Exosomes; Gemcitabine; Mesenchymal stem cells; Pancreatic cancer.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Schematic diagram of approaches for cargoes loading to exosomes. The scheme illustrates the approaches including biological, chemical, and physical methods, which are used to load cargoes, such as drugs, RNA interference, nucleotides, and proteins, into or onto the exosomes. RNAi: RNA interference; DEAE: Diethylaminoethyl; PEI: Polyethylenimine.
See this image and copyright information in PMC

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