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Editorial
. 2024 Dec 24;12(6):120.
doi: 10.21037/atm-24-86. Epub 2024 Oct 14.

C9orf72 role in myeloid cells: new perspectives in the investigation of the neuro-immune crosstalk in amyotrophic lateral sclerosis and frontotemporal dementia

Maria Elena Cicardi  1 , Davide Trotti  1
Affiliations
Editorial

C9orf72 role in myeloid cells: new perspectives in the investigation of the neuro-immune crosstalk in amyotrophic lateral sclerosis and frontotemporal dementia

Maria Elena Cicardi et al. Ann Transl Med. .
No abstract available

Keywords: C9orf72; Neurodegenerative diseases (NDs); microglia; myeloid cells; neuroinflammation.

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Conflict of interest statement

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://atm.amegroups.com/article/view/10.21037/atm-24-86/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Hematopoietic stem and progenitor populations targeted for Cre recombination. Limone et al. crossed mice carrying two copies of a floxed C9orf72 allele with seven different Cre recombinase mouse lines to generate cohorts of conditional knock-out mice and littermate controls. Vav1-Cre and Mx1-Cre depleting C9orf72 from all hematopoietic cells; LysM-Cre for myeloid lineage; CD2-Cre for common lymphoid progenitors; CD4-Cre for CD4+ and CD8+ T cells; CD19-Cre for B cells; Foxp3-Cre for Treg cells. Created with BioRender.com. LysM, lysin motif.
See this image and copyright information in PMC

Comment on

  • Myeloid and lymphoid expression of C9orf72 regulates IL-17A signaling in mice.
    Limone F, Couto A, Wang JY, Zhang Y, McCourt B, Huang C, Minkin A, Jani M, McNeer S, Keaney J, Gillet G, Gonzalez RL, Goodman WA, Kadiu I, Eggan K, Burberry A. Limone F, et al. Sci Transl Med. 2024 Jan 31;16(732):eadg7895. doi: 10.1126/scitranslmed.adg7895. Epub 2024 Jan 31. Sci Transl Med. 2024. PMID: 38295187 Free PMC article.

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