Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2024 Dec 24;12(6):119.
doi: 10.21037/atm-24-104. Epub 2024 Dec 2.

Risk and progression of frontotemporal dementia in carriers of the TMEM106B protective genotype and its relationship with TDP-43 pathology

Karina Braga Gomes  1
Affiliations
Editorial

Risk and progression of frontotemporal dementia in carriers of the TMEM106B protective genotype and its relationship with TDP-43 pathology

Karina Braga Gomes. Ann Transl Med. .
No abstract available

Keywords: Frontotemporal dementia (FTD); TDP-43; TMEM106B; neurodegenerative disorder.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The author has completed the ICMJE uniform disclosure form (available at https://atm.amegroups.com/article/view/10.21037/atm-24-104/coif). The author reports that she received a research fellowship from the Brazilian government (CNPq). The author has no other conflicts of interest to declare.

Figures

Figure 1
Figure 1
Schematic structure of TMEM106B. N-terminal domain, transmembrane domain, and C-terminal domain indicating the site that may become cleaved, corresponding to the aggregation-prone region.
See this image and copyright information in PMC

Comment on

  • TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia.
    Marks JD, Ayuso VE, Carlomagno Y, Yue M, Todd TW, Hao Y, Li Z, McEachin ZT, Shantaraman A, Duong DM, Daughrity LM, Jansen-West K, Shao W, Calliari A, Bejarano JG, DeTure M, Rawlinson B, Casey MC, Lilley MT, Donahue MH, Jawahar VM, Boeve BF, Petersen RC, Knopman DS, Oskarsson B, Graff-Radford NR, Wszolek ZK, Dickson DW, Josephs KA, Qi YA, Seyfried NT, Ward ME, Zhang YJ, Prudencio M, Petrucelli L, Cook CN. Marks JD, et al. Sci Transl Med. 2024 Jan 17;16(730):eadf9735. doi: 10.1126/scitranslmed.adf9735. Epub 2024 Jan 17. Sci Transl Med. 2024. PMID: 38232138 Free PMC article.

References

    1. Marks JD, Ayuso VE, Carlomagno Y, et al. TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia. Sci Transl Med 2024;16:eadf9735. 10.1126/scitranslmed.adf9735 - DOI - PMC - PubMed
    1. Bang J, Spina S, Miller BL. Frontotemporal dementia. Lancet 2015;386:1672-82. 10.1016/S0140-6736(15)00461-4 - DOI - PMC - PubMed
    1. Tartaglia MC, Mackenzie IRA. Recent Advances in Frontotemporal Dementia. Can J Neurol Sci 2023;50:485-94. 10.1017/cjn.2022.69 - DOI - PubMed
    1. Vieira RT, Caixeta L, Machado S, et al. Epidemiology of early-onset dementia: a review of the literature. Clin Pract Epidemiol Ment Health 2013;9:88-95. 10.2174/1745017901309010088 - DOI - PMC - PubMed
    1. Gorno-Tempini ML, Hillis AE, Weintraub S, et al. Classification of primary progressive aphasia and its variants. Neurology 2011;76:1006-14. 10.1212/WNL.0b013e31821103e6 - DOI - PMC - PubMed