Cancer statistics, 2025

Abstract

Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population-based cancer occurrence and outcomes using incidence data collected by central cancer registries (through 2021) and mortality data collected by the National Center for Health Statistics (through 2022). In 2025, 2,041,910 new cancer cases and 618,120 cancer deaths are projected to occur in the United States. The cancer mortality rate continued to decline through 2022, averting nearly 4.5 million deaths since 1991 because of smoking reductions, earlier detection for some cancers, and improved treatment. Yet alarming disparities persist; Native American people bear the highest cancer mortality, including rates that are two to three times those in White people for kidney, liver, stomach, and cervical cancers. Similarly, Black people have two-fold higher mortality than White people for prostate, stomach, and uterine corpus cancers. Overall cancer incidence has generally declined in men but has risen in women, narrowing the male-to-female rate ratio (RR) from a peak of 1.6 (95% confidence interval, 1.57-1.61) in 1992 to 1.1 (95% confidence interval, 1.12-1.12) in 2021. However, rates in women aged 50-64 years have already surpassed those in men (832.5 vs. 830.6 per 100,000), and younger women (younger than 50 years) have an 82% higher incidence rate than their male counterparts (141.1 vs. 77.4 per 100,000), up from 51% in 2002. Notably, lung cancer incidence in women surpassed that in men among people younger than 65 years in 2021 (15.7 vs. 15.4 per 100,000; RR, 0.98, p = 0.03). In summary, cancer mortality continues to decline, but future gains are threatened by rampant racial inequalities and a growing burden of disease in middle-aged and young adults, especially women. Continued progress will require investment in cancer prevention and access to equitable treatment, especially for Native American and Black individuals.

Keywords: cancer cases; cancer statistics; death rates; incidence; mortality.

FIGURE 1

Leading sites of estimated new cancer cases and deaths by sex, United States, 2025. Estimates exclude US territories and are rounded to the nearest 10, and cases exclude basal cell and squamous cell skin cancers and in situ carcinoma except urinary bladder. Ranking is based on modeled projections and may differ from the most recent observed data.

FIGURE 2

Trends in cancer incidence (1975–2021) and mortality (1975–2022) rates by sex, United States. Rates are age adjusted to the 2000 US standard population, and incidence rates are adjusted for delays in case reporting. Incidence data for 2020 are shown separate from trend lines.

FIGURE 3

Trends in cancer incidence by age and sex, United States, 1998–2021. Rates are age adjusted to the 2000 US standard population and adjusted for delays in case reporting. Data for 2020 are shown separate from trend lines.

FIGURE 4

Trends in incidence rates for selected cancers by sex, United States, 1975 to 2021. Rates are age adjusted to the 2000 US standard population and adjusted for delays in reporting. Data for 2020 are shown separate from trend lines. ^aExcludes appendix. ^bIncludes intrahepatic bile duct.

FIGURE 5

Five‐year relative survival rates for selected cancers by race and stage at diagnosis, United States, 2014 to 2020. All patients were followed through 2021. White and Black race are exclusive of Hispanic ethnicity. ^aExcludes appendix. ^bStandard error is between 5 and 10 percentage points.

FIGURE 6

Stage distribution for selected cancers by race, United States, 2017 to 2021. White and Black race are exclusive of Hispanic ethnicity. Stage categories may not sum to 100% because of rounding. ^aExcludes appendix.

FIGURE 7

Trends in cancer mortality rates by sex overall and for selected cancers by sex, United States, 1930 to 2022. Rates are age adjusted to the 2000 US standard population. Numerator data for cancers of the lung and bronchus, colon and rectum, liver, and uterus differ from the contemporary time period because of improvements in International Classification of Diseases coding over time. For example, rates for lung and bronchus include pleura, trachea, mediastinum, and other respiratory organs.

FIGURE 8

Total number of cancer deaths averted during 1991 to 2022 in men and 1992 to 2022 in women, United States. The blue line represents the actual number of cancer deaths recorded in each year; the red line represents the number of cancer deaths that would have been expected if cancer death rates had remained at their peak.