Effect of condensed heat acclimation on thermophysiological adaptations, hypoxic cross-tolerance, exercise performance, and deacclimation

Abstract

Short duration heat acclimation (HA) (≤5 daily heat exposures) elicits incomplete adaptation compared with longer interventions, possibly due to the lower accumulated thermal "dose." It is unknown if matching thermal "dose" over a shorter timescale elicits comparable adaptation to a longer intervention. Using a parallel-groups design, we compared: 1) "condensed" HA (CHA; n = 17 males) consisting of 4 × 75 min·day^-1 heat exposures [target rectal temperature (T_rec) = 38.5 °C] for two consecutive days, with 2) "traditional" HA (THA; n = 15 males) consisting of 1 × 75 min·day^-1 heat exposure (target T_rec = 38.5°C) for eight consecutive days. Physiological responses to exercise heat stress, hypoxia, and normoxic exercise performance were evaluated pre- and postintervention. Thermal (T_rec over final 45 min: CHA = 38.45 ± 0.17°C, THA = 38.53 ± 0.13°C, P = 0.126) and cardiovascular strain were not different during interventions, indicating similar thermal "dose," although CHA had lower sweating rate, higher starting T_rec, and greater inflammation, gastrointestinal permeability, and renal stress (P < 0.05). However, CHA elicited an array of thermophysiological adaptations that did not differ from THA [reduced indices of peak thermal (e.g., Δ peak T_rec CHA = -0.28 ± 0.26°C, THA = -0.36 ± 0.17°C, P = 0.303) and cardiovascular strain, inflammation, and renal stress; blood and plasma volume expansion; improved perceptual indices], although improvements in resting thermal strain (e.g., Δ resting T_rec CHA = -0.14 ± 0.21°C, THA = -0.35 ± 0.29°C, P = 0.027) and sweating rate were less with CHA. Both interventions improved aspects of hypoxic tolerance, but effects on temperate normoxic exercise indices were limited. The diminished thermal strain was well-maintained over a 22-day decay period. In conclusion, CHA could represent a viable acclimation option for time-restricted young healthy males preparing for a hot, and possibly high-altitude, environment.NEW & NOTEWORTHY This study has shown, for the first time, that a novel condensed heat acclimation program can elicit an array of thermophysiological adaptations, many of which do not differ from traditional heat acclimation. These findings suggest that accumulated thermal "dose" is an important factor contributing to the adaptive responses to heat stress and that condensed heat acclimation may represent a viable option for time-restricted individuals (e.g., military personnel, firefighters, and athletes) preparing to enter a hot environment.

Keywords: acclimatization; cross-tolerance; environmental physiology.