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Review
. 2025:108:1-49.
doi: 10.1007/978-3-031-75980-2_1.

Basic Epigenetic Mechanisms

James R Davie  1 , Hedieh Sattarifard  2 , Sadhana R N Sudhakar  2 , Chris-Tiann Roberts  2 , Tasnim H Beacon  2 , Ishdeep Muker  2 , Ashraf K Shahib  2 , Mojgan Rastegar  2
Affiliations
Review

Basic Epigenetic Mechanisms

James R Davie et al. Subcell Biochem. 2025.

Abstract

The human genome consists of 23 chromosome pairs (22 autosomes and one pair of sex chromosomes), with 46 chromosomes in a normal cell. In the interphase nucleus, the 2 m long nuclear DNA is assembled with proteins forming chromatin. The typical mammalian cell nucleus has a diameter between 5 and 15 μm in which the DNA is packaged into an assortment of chromatin assemblies. The human brain has over 3000 cell types, including neurons, glial cells, oligodendrocytes, microglial, and many others. Epigenetic processes are involved in directing the organization and function of the genome of each one of the 3000 brain cell types. We refer to epigenetics as the study of changes in gene function that do not involve changes in DNA sequence. These epigenetic processes include histone modifications, DNA modifications, nuclear RNA, and transcription factors. In the interphase nucleus, the nuclear DNA is organized into different structures that are permissive or a hindrance to gene expression. In this chapter, we will review the epigenetic mechanisms that give rise to cell type-specific gene expression patterns.

Keywords: Chromatin structure; DNA modifications; Epigenetics; Histone modifications; Regulation of gene expression.

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References

    1. Abini-Agbomson S, Gretarsson K, Shih RM et al (2023) Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1. Mol Cell 83:2872–2883.e7. https://doi.org/10.1016/J.MOLCEL.2023.07.020 - DOI - PubMed
    1. Adam K, Hunter T (2018) Histidine kinases and the missing phosphoproteome from prokaryotes to eukaryotes. Lab Investig 98:233–247. https://doi.org/10.1038/LABINVEST.2017.118 - DOI - PubMed
    1. Agredo A, Kasinski AL (2023) Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease. Front Genet 14. https://doi.org/10.3389/FGENE.2023.1243395
    1. Ahmad K, Brahma S, Henikoff S (2024) Epigenetic pioneering by SWI/SNF family remodelers. Mol Cell 84:194. https://doi.org/10.1016/J.MOLCEL.2023.10.045 - DOI - PubMed
    1. Alexander DC, Corman T, Mendoza M et al (2022) Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation. Proc Natl Acad Sci USA 119:e2114758119. https://doi.org/10.1073/PNAS.2114758119 - DOI - PubMed - PMC

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