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Review
. 2024 Dec 16;16(12):e75844.
doi: 10.7759/cureus.75844. eCollection 2024 Dec.

Nuclear Factor of Activated T Cells (NFAT) Proteins as Targeted Molecules in Diseases: A Narrative Review

Mohadese Mozafari  1 , Siti Nurnasihah Md Hashim  1 , Khairul Bariah Ahmad Amin Noordin  1 , Siti Aishah Zainal  1 , Ahmad Azlina  1   2   3
Affiliations
Review

Nuclear Factor of Activated T Cells (NFAT) Proteins as Targeted Molecules in Diseases: A Narrative Review

Mohadese Mozafari et al. Cureus. .

Abstract

The nuclear factor of activated T cells (NFAT) is a key player in the NFAT pathway, regulating various cellular processes physiologically and pathologically. NFAT signaling is implicated in developing multiple diseases, such as cancer progression, that are associated with angiogenesis. Despite numerous studies on NFAT, there is still a dearth of information on the proteins and signaling pathway compared to other established pathways. With five NFAT proteins in the spotlight, this review aims to update the understanding of their roles and signaling by analyzing the most recent studies on the NFAT pathway. The recent insights into NFAT proteins and their association with diseases enhance our understanding of these proteins and open the possibility of developing therapeutic strategies for such diseases.

Keywords: angiogenesis; cancer; endothelial cell; nfat pathway; nfat proteins; stem cell.

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Conflict of interest statement

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: Ethical issues are not applicable. All authors declare that there is no potential conflict of interest. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

References

    1. Insights in Hodgkin lymphoma angiogenesis. Marinaccio C, Nico B, Maiorano E, Specchia G, Ribatti D. Leuk Res. 2014;38:857–861. - PubMed
    1. Identification of a putative regulator of early T cell activation genes. Shaw JP, Utz PJ, Durand DB, Toole JJ, Emmel EA, Crabtree GR. https://pubmed.ncbi.nlm.nih.gov/3260404/ Science. 1988;241:202–205. - PubMed
    1. Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor. Mognol GP, González-Avalos E, Ghosh S, et al. Proc Natl Acad Sci U S A. 2019;116:9959–9968. - PMC - PubMed
    1. TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging. Lee HH, An SM, Ye BJ, et al. Nat Commun. 2019;10:3536. - PMC - PubMed
    1. NFAT signaling: choreographing the social lives of cells. Crabtree GR, Olson EN. Cell. 2002;109:0–79. - PubMed

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