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. 2024 Dec 16;16(12):e75831.
doi: 10.7759/cureus.75831. eCollection 2024 Dec.

Assessment of Total Antioxidant Capacity and Malondialdehyde Levels in Obese Patients With Periodontitis

Suzan M Taha Jr  1 , Faraedon M Zardawi Sr  2 , Chenar Anwar Sr  3 , Saeed A Mohammed Jr  1 , Hashim Mousa Sr  4
Affiliations

Assessment of Total Antioxidant Capacity and Malondialdehyde Levels in Obese Patients With Periodontitis

Suzan M Taha Jr et al. Cureus. .

Abstract

Background and objectives Obesity is increasingly recognized as a serious chronic health issue worldwide. Numerous studies have highlighted its association with periodontal disease. Both obesity and periodontal disease may be connected through oxidative stress. The purpose of this study is to determine whether periodontal problems are linked to obese people's greater vulnerability to oxidative stress. Methods A total of 120 individuals of both sexes (69 females and 51 males), with mean ages of 37.8 ± 9 years, were randomly assigned to one of three groups in a case-control study: 40 were in the control group, 40 were in the obese without periodontitis group, and 40 were in the obese with periodontitis group. The serum of the three groups was then evaluated for biochemical markers (total antioxidant capacity (TAC), malondialdehyde (MDA)) and a clinical periodontal parameter (clinical attachment level, CAL). Results The findings indicated that 30.7% of men and 41.6% of women participated in the study. Within each group, there was a significant difference (p < 0.001) in TAC and MDA levels between the obese and control groups, as well as between those with and without periodontitis. The obese group without periodontitis had a substantially larger mean waist circumference (93 ± 11.9) than the control group (86.0 ± 7.8), and the differences were statistically significant (p < 0.001). Conclusion Anthropometric and demographic measurements revealed no significant differences between obese individuals with periodontitis and those without it. Our results suggest that, in obese individuals, the onset of oxidative stress and reduced antioxidant capacity may act as a pathophysiological link to periodontitis.

Keywords: body mass index; malondialdehyde; obesity; oxidative stress; total antioxidant capacity.

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Conflict of interest statement

Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Ethical Committee of University of Duhok issued approval N: 17/8. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

References

    1. Obesity and its related diseases: a new escalating alarming in global health. Mohajan D, Mohajan HK. J Innov Med Res. 2023;2:12–23.
    1. Obesity and the risk of myocardial infarction in 27 000 participants from 52 countries: a case-control study. Yusuf S, Hawken S, Ôunpuu S, et al. Lancet. 2005;1016:140–6736. - PubMed
    1. Association between periodontal disease and atherosclerotic cardiovascular diseases: revisited. Zardawi F, Gul S, Abdulkareem A, Sha A, Yates J. Front Cardiovasc Med. 2020;7:625579. - PMC - PubMed
    1. The role of obesity in type 2 diabetes mellitus—an overview. Chandrasekaran P, Weiskirchen R. Int J Mol Sci. 2024;25:1882. - PMC - PubMed
    1. Balan P, Udawatte N, Chandrasekaran CP, et al. Pathological Basis of Oral and Maxillofacial Diseases. Hoboken, New Jersey: John Wiley & Sons; 2024. Human microbiome in health and disease with reference to dysbiosis in dental caries and periodontal diseases; pp. 293–309.

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