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. 2024 Dec 15;16(12):7749-7756.
doi: 10.62347/ZXPV4184. eCollection 2024.

Correlation between peripheral blood inflammatory markers and delayed cerebral ischemia after intracerebral hemorrhage

Yuhua Wang  1 , Aijun Liu  1 , Fengju Hui  1 , Ning Han  1 , Wei Zhang  1 , Yinzhou Sang  2
Affiliations

Correlation between peripheral blood inflammatory markers and delayed cerebral ischemia after intracerebral hemorrhage

Yuhua Wang et al. Am J Transl Res. .

Abstract

Objective: To assess the predictive value of peripheral blood inflammatory markers for delayed cerebral ischemia (DCI) in patients with intracerebral hemorrhage (ICH) and explore methods for early intervention.

Methods: This single-center retrospective study reviewed medical records of ICH patients admitted to Cangzhou People's Hospital over a 12-month period from January 2022 to December 2023. Of the 150 identified patients with ICH, including 80 patients without DCI (control group) and 70 with DCI (observation group). Demographics and blood biochemical markers during hospitalization were recorded. Binary logistic regression was used to identify independent factors influencing DCI occurrence.

Results: Significant differences were observed between the two groups in neutrophil percentage, lymphocyte percentage, lymphocytes absolute and neutrophil-to-lymphocyte ratio (NLR) (all P<0.05). Logistic regression analysis identified mRS score, lymphocyte percentage, educational level, uric acid, neutrophils percentage, and NLR as independent risk factors for DCI.

Conclusion: Neutrophil percentage and NLR are independent factors influencing delayed cerebral ischemia after intracerebral hemorrhage. These markers are readily accessible and may provide valuable insights for early ICH management.

Keywords: Peripheral blood inflammatory; delayed cerebral ischemia; intracerebral hemorrhage.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Comparison of the peripheral blood inflammatory markers between the two groups. A: Neutrophil percentage; B: Lymphocyte percentage; C: Lymphocytes absolute; D: NLR. Note: NLR: Neutrophil-to-Lymphocyte Ratio. Compared to control group, *P<0.05.
See this image and copyright information in PMC

References

    1. Sheth KN. Spontaneous intracerebral hemorrhage. N Engl J Med. 2022;387:1589–1596. - PubMed
    1. Sun L, Clarke R, Bennett D, Guo Y, Walters RG, Hill M, Parish S, Millwood IY, Bian Z, Chen Y, Yu C, Lv J, Collins R, Chen J, Peto R, Li L, Chen Z China Kadoorie Biobank Collaborative Group; International Steering Committee; International Co-ordinating Centre, Oxford; National Co-ordinating Centre, Beijing; Regional Co-ordinating Centres. Causal associations of blood lipids with risk of ischemic stroke and intracerebral hemorrhage in Chinese adults. Nat Med. 2019;25:569–574. - PMC - PubMed
    1. Williams S, Glaser K, Ray B. Strokes and predictors of outcomes. Crit Care Nurs Clin North Am. 2023;35:1–15. - PubMed
    1. Scalia G, Silven MP, Costanzo R, Chaurasia B, Furnari M, Iacopino DG, Nicoletti GF, Umana GE. Remote intracerebral hemorrhage following craniotomy for an intracerebral hematoma: a case report. Clin Case Rep. 2023;11:e8271. - PMC - PubMed
    1. Colasurdo M, Chen H, Gandhi D. MR imaging techniques for acute ischemic stroke and delayed cerebral ischemia following subarachnoid hemorrhage. Neuroimaging Clin N Am. 2024;34:203–214. - PubMed

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