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. 2025 Jan 14;6(2):e70070.
doi: 10.1002/mco2.70070. eCollection 2025 Feb.

Transient pre-seizure inhibition of lateral hypothalamic orexin neurons: a novel possibility for seizure control

Yuang Gu  1 , Yi Wang  1 , Heming Cheng  1
Affiliations

Transient pre-seizure inhibition of lateral hypothalamic orexin neurons: a novel possibility for seizure control

Yuang Gu et al. MedComm (2020). .
No abstract available

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Calcium‐based fiber photometry combined with electroencephalogram (EEG) recording reveals a positive correlation between the pre‐seizure activity of hypocretin/orexin neurons (HONs) and subsequent optokindling seizures. Pre‐seizure optogenetic inhibition of HON activity results in transient anti‐seizure effects, whereas high‐frequency stimulation (HFS) of the lateral hypothalamus (LH) produces a prolonged effect. These findings offer novel insights for the development of seizure prediction and epilepsy treatment; however, several issues remain to be answered. Question 1: What is the role of pre‐seizure activity of HONs in chronic seizure models? Question 2: Why does HFS inhibit hyperactivity in HONs compared to low‐frequency stimulation (LFS)? Question 3: What is the role of HONs in other comorbidities associated with epilepsy?
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