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. 2024 Dec 31;13(12):2221-2232.
doi: 10.21037/tp-24-308. Epub 2024 Dec 27.

Birth weight and ponderal index percentiles for twins based on sex and chorionicity in a center of Guangdong Province, China

Qian Liu  1 , Jiying Wen  2 , Liyuan Fang  1 , Yanlin Huang  1 , Tengzi Rao  1 , Xiaomei Shi  1 , Jing Wu  1
Affiliations

Birth weight and ponderal index percentiles for twins based on sex and chorionicity in a center of Guangdong Province, China

Qian Liu et al. Transl Pediatr. .

Abstract

Background: Intrauterine growth restriction (IUGR) which is judged based on birth weight and gestational age, is associated with increased neonatal mobility and mortality and also has a further impact on physical and mental health during later in life. Using the birth weight percentile for singletons to assess twins might not accurately reflect the growth status of the twins; this could potentially lead to an incorrect evaluation of growth-restricted children. For a more precise assessment of twin newborns, it is beneficial to utilize twin-specific birth weight percentile curves and ponderal index (PI) curves that consider factors such as birth order and sex. The aim of this study is to establish a contemporary up-to-date method that provides sex-specific percentiles for birth weight and the PI of twin neonates, categorized by gestational age and differentiated by chorionicity within a defined cross-sectional study.

Methods: We retrospectively analyzed the birth weight and PI percentile of 3,433 twins born at a gestational age between 25 and 40 weeks based on sex and chorionicity, between 2015 and 2020 in a single center in southern China. The smoothed percentile curves were drawn via generalized additive models for location, scale and shape (GAMLSS).

Results: A total of 3,433 live-born twins were included in this study and consisted of 366 monochorionic girls, 405 monochorionic boys, 1,237 dichorionic girls and 1,425 dichorionic boys. Compared with dichorionic twins, the mean birth weight of monochorionic twins was significantly lower and the gestational week of delivery was earlier. The calculated 50th percentile birth weight values for twin boys were higher than those for girls based on the same chorionicity, except for those male monochorionic twins who were born before week 31 of gestation.

Conclusions: The birth weight and PI percentile charts for neonates, categorized by sex and chorionicity, serve as valuable tools for assessing the wellbeing of twin infants. Utilizing these charts could reduce the overdiagnosis of small for gestational (SGA) age in normally growing twins.

Keywords: Birth weight percentile; chorionicity; ponderal index (PI); twin pregnancy.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-24-308/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Percentile chart of birth weight based on gestational age for monochorionic female twins.
Figure 2
Figure 2
Percentile chart of ponderal index based on gestational age for monochorionic female twins.
Figure 3
Figure 3
Percentile chart of birth weight based on gestational age for monochorionic male twins.
Figure 4
Figure 4
Percentile chart of ponderal index based on gestational age for monochorionic male twins.
Figure 5
Figure 5
Percentile chart of birth weight based on gestational age for dichorionic female twins.
Figure 6
Figure 6
Percentile chart of ponderal index based on gestational age for dichorionic female twins.
Figure 7
Figure 7
Percentile chart of birth weight based on gestational age for dichorionic male twins.
Figure 8
Figure 8
Percentile chart of ponderal index based on gestational age for dichorionic male twins.
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References

    1. Liu H, Wang B, Lu T, et al. Safety and efficacy of probiotics in the prevention of necrotizing enterocolitis in premature and/or low-birthweight infants: a systematic review and meta-analysis. Transl Pediatr 2022;11:249-59. 10.21037/tp-22-27 - DOI - PMC - PubMed
    1. Belbasis L, Savvidou MD, Kanu C, et al. Birth weight in relation to health and disease in later life: an umbrella review of systematic reviews and meta-analyses. BMC Med 2016;14:147. 10.1186/s12916-016-0692-5 - DOI - PMC - PubMed
    1. Wang YX, Li Y, Rich-Edwards JW, et al. Associations of birth weight and later life lifestyle factors with risk of cardiovascular disease in the USA: A prospective cohort study. EClinicalMedicine 2022;51:101570. 10.1016/j.eclinm.2022.101570 - DOI - PMC - PubMed
    1. Grove BJ, Lim SJ, Gale CR, et al. Birth weight and cognitive ability in adulthood: A systematic review and meta-analysis. Intelligence 2017,61:146-58. 10.1016/j.intell.2017.02.001 - DOI
    1. Chen R, Ji L, Chen Y, et al. Weight-to-height ratio and body roundness index are superior indicators to assess cardio-metabolic risks in Chinese children and adolescents: compared with body mass index and a body shape index. Transl Pediatr 2022;11:318-29. 10.21037/tp-21-479 - DOI - PMC - PubMed

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