Magnetic resonance imaging evaluation and nuclear receptor binding SET domain protein 1 mutation in the Sotos syndrome with attention-deficit/hyperactivity disorder

Abstract

Sotos syndrome is characterized by overgrowth features and is caused by alterations in the nuclear receptor binding SET domain protein 1 gene. Attention-deficit/hyperactivity disorder (ADHD) is considered a neurodevelopment and psychiatric disorder in childhood. Genetic characteristics and clinical presentation could play an important role in the diagnosis of Sotos syndrome and ADHD. Magnetic resonance imaging (MRI) has been used to assess medical images in Sotos syndrome and ADHD. The images process is considered to display in MRI while wavelet fusion has been used to integrate distinct images for achieving more complete information in single image in this editorial. In the future, genetic mechanisms and artificial intelligence related to medical images could be used in the clinical diagnosis of Sotos syndrome and ADHD.

Keywords: Attention-deficit/hyperactivity disorder; Genetic mutation; Magnetic resonance imaging; Sotos syndrome; Wavelet fusion.

Figure 1

Magnetic resonance imaging of soft-tissue sarcoma in a female child with Sotos syndrome. A: Axial T1-weighted magnetic resonance imaging (MRI) with gray level showed isointense in the muscle with a high signal; B: Short tau inversion recovery MRI with gray level showed a heterogeneous mass with a high signal; C: Wavelet fusion was performed by integrating both A and B. Arrows show an ill-defined mass.

Figure 2

Magnetic resonance imaging of brain areas with cerebral blood flow in children with attention-deficit/hyperactivity disorder. A and B: Lines of magnetic resonance imaging with gray level was applied to represent distinct baselines of cerebral blood flow at high or low density; C: Wavelet fusion was used to display the different cerebral blood flow in the pooled image. R: Right; L: Left.