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. 1985 Jan;328(3):324-6.
doi: 10.1007/BF00515561.

Release of cholecystokinin-immunoreactivity into the vascular bed of the guinea-pig small intestine during peristalsis

J Donnerer, D K Meyer, P Holzer, F Lembeck

Release of cholecystokinin-immunoreactivity into the vascular bed of the guinea-pig small intestine during peristalsis

J Donnerer et al. Naunyn Schmiedebergs Arch Pharmacol. 1985 Jan.

Abstract

The release of cholecystokinin-immunoreactivity (CCK-IR) into the venous effluate of the isolated and vascularly perfused guinea-pig small intestine was measured. Raising the intraluminal pressure by 5 mbar for 8 min initiated peristalsis and was associated with an increased release of CCK-IR. The ganglion stimulant dimethylphenyl-piperazinium failed to alter the release of CCK-IR. The results are discussed in the light of a possible involvement of CCK-containing neurones in intestinal peristalsis.

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