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Case Reports
. 2025 Jan 18;24(1):6.
doi: 10.1186/s12941-024-00771-7.

Persistent NK cell deficiency associated with pulmonary cryptococcosis

Martin Martinot  1 , Shu Shun Li  2 , Catherine Farnarier  3 , Cléa Dubrou  3 , Christelle Piperoglou  3 , Christopher H Mody  2 , Frederic Vely  3   4
Affiliations
Case Reports

Persistent NK cell deficiency associated with pulmonary cryptococcosis

Martin Martinot et al. Ann Clin Microbiol Antimicrob. .

Abstract

We describe pulmonary cryptococcosis in a 28-year-old previously healthy man. Exhaustive immunological investigations revealed a primary NK cell deficiency associated with a secondary impaired anti-Cryptococcus CD8 lymphocyte response and the expansion of a CD8Vβ14 + T cell clone. This case illustrates the potential role of NK cells in immunity against Cryptococcus.

Keywords: Cryptococcus; CD8 clonotype; NK cell deficiency; NK cells; Vβ14 repertoire.

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Conflict of interest statement

Declarations. Consent for publication: Written consent for publication was obtained from the patient. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Images of pulmonary nodules (arrows) related to Cryptococcus infection on chest computed tomography in 2009 (left). Regression of lesions 2 years later (right)
See this image and copyright information in PMC

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