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. 2025 Jan 3;10(1):1207-1225.
doi: 10.1021/acsomega.4c08669. eCollection 2025 Jan 14.

Global Advancements in Bioactive Material Manufacturing for Drug Delivery: A Comprehensive Study

Rafael Leandro Fernandes Melo  1   2 , Dayana Nascimento Dari  3 , Francisco Izaias da Silva Aires  3 , Francisco Simão Neto  4 , Tiago Melo Freire  2 , Bruno Caio Chaves Fernandes  5 , Pierre Basílio Almeida Fechine  2 , João Maria Soares  6 , José Cleiton Sousa Dos Santos  2
Affiliations

Global Advancements in Bioactive Material Manufacturing for Drug Delivery: A Comprehensive Study

Rafael Leandro Fernandes Melo et al. ACS Omega. .

Abstract

Manufacturing bioactive materials for drug delivery involves developing materials that interact with biological tissues to release drugs in a controlled and targeted manner. The goal is to optimize therapeutic efficacy and reduce side effects by combining knowledge from materials engineering, biology, and pharmacology. This study presents a detailed bibliometric analysis, exploring the keywords "manufacturing," "bioactive materials," and "drug delivery" to identify and highlight significant advancements in the field. From the Web of Science, 36,504 articles were analyzed, with 171 selected for a deeper analysis, identifying key journals, countries, institutions, and authors. The results highlight the field's interdisciplinary nature, with keywords grouped into four main themes, including regenerative medicine, scaffolds, three-dimensional (3D) printing, bioactive glass, and tissue engineering. Future research in this area will focus on more effective and precise systems using technologies like 3D printing and nanotechnology to enhance the customization and control of drug release, aiming for more efficient and targeted therapies.

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Conflict of interest statement

The authors declare no competing financial interest.

Figures

Figure 1
Figure 1
Methodological steps for the bibliometric analysis.
Figure 2
Figure 2
Evolution of the number of publications from 2014 to 2024.
Figure 3
Figure 3
Bibliometric analysis of research on the manufacture of bioactive materials for drug delivery. Ranking of the top 10 journals with the most publications in the area.
Figure 4
Figure 4
Bibliometric analysis of research on the manufacture of bioactive materials for drug delivery. (a) Network analysis of the most influential countries. (b) Network analysis of the most influential institutions. (c) Network analysis of the most influential authors.
Figure 5
Figure 5
Bibliometric analysis of research on the manufacture of bioactive materials for drug delivery. (a) Cooperation map shows collaborations between all countries published in this area. (b) Sankey graph showing the interconnection between countries, authors, and institutions.
Figure 6
Figure 6
Distributions of research areas for articles on the manufacturing of bioactive materials for drug delivery.
Figure 7
Figure 7
Network analysis of clusters formed by the main keywords related to manufacturing bioactive materials for drug delivery. (a) Clusters formed by the main keywords. (b) Temporal analysis of clusters. (c) Temperature gradient analysis of the clusters.
Figure 8
Figure 8
Bibliometric analysis of research on the manufacture of bioactive materials for drug delivery. (a) Evolution of the topic’s main keywords over the last 10 years. (b) Map of the main clusters correlating the impact and centrality of the topic.
Figure 9
Figure 9
Bibliometric analysis of research on the manufacture of bioactive materials for drug delivery. (a) Thematic map correlating the themes into emerging, niche, driving, and basic themes. (b) Factor analysis of clusters.
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