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. 2024 Sep 13:4:50.
doi: 10.3310/nihropenres.13623.1. eCollection 2024.

Temporal Trends in Parkinson's Disease Related Mortality from 1999-2020: A National Analysis

Balamrit Singh Sokhal  1 , Sowmya Prasanna Kumar Menon  1 , Thomas Shepherd  1 , Sara Muller  1 , Amit Arora  1   2 , Christian Mallen  1
Affiliations

Temporal Trends in Parkinson's Disease Related Mortality from 1999-2020: A National Analysis

Balamrit Singh Sokhal et al. NIHR Open Res. .

Abstract

Introduction: Parkinson's disease (PD) is the most common neurodegenerative movement disorder and is associated with significant disability. The prevalence is rising, and studies have reported potential sex and race disparities in patient outcomes. Data about the demographic trends in PD-related mortality in the United States (US) is limited. This descriptive study aimed to report the national demographic trends in PD-related mortality over a 20-year period.

Methods: The US Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiological Research (CDC-WONDER) Underlying Cause of Death database from January 1999 to December 2020 was used to determine the PD-related age adjusted mortality rate (AAMR) stratified by age, sex, ethnicity and geographic area, with the 1999 deaths as the reference group. Annual percentage change (APC) for AAMR was then calculated using Joinpoint regression.

Results: There were 515,884 PD-related deaths in the study period. The AAMR increased from 5.3 per 100,000 population in 1999 to 9.8 per 100,000 in 2020. Males had consistently higher AAMR than females and white race had consistently higher overall AAMR (7.6 per 100,000), followed by American Indians/Alaska Natives (4.4 per 100,000), Asians/Pacific Islanders (4.1 per 100,000) and Black/African Americans (3.4 per 100,000). The Midwest had the highest AAMR followed by West, South and Northeast. Utah, Idaho and Minnesota had the highest state-level AAMR.

Conclusions: This study identified significant age, sex, race and geographic disparities in PD-related mortality in the US. Older age, male sex, white race and Midwest locality were associated with the highest AAMR.

Keywords: Parkinson’s Disease; Mortality; Outcomes; Epidemiology..

Plain language summary

Parkinson's disease (PD) is a common disease that impacts the brain and as a result, movement. One in 37 people will be diagnosed with PD in their lifetime, and the risk of developing PD increases with age. PD can lead to variety of complications such as falls, depression, and death. This research aimed to summarise the demographic trends in PD-related death in the United States from 1999–2020 using death certificate data. There were 515,884 PD-related deaths in the study period. Death rates increased from 5.3 per 100,000 population in 1999 to 9.8 per 100,000 in 2020. In terms of demographics, firstly, male sex had a higher rate than female sex. Secondly, white race had death rate than American Indians/Alaska Natives, Asians/Pacific Islanders and Black/African Americans, Finally, the Midwest had a higher death rate than the West, South and Northeast. These results could be because PD is more common in these groups. Future research could investigate underlying reasons behind disparities in mortality. In summary, PD is a significant cause of death in the US and there are differences in demographic trends in PD-related deaths. The number of deaths from PD per population count is higher with older ages, in males, people of white race and in the Midwest. Knowledge of these trends is important to build healthcare services around this growing population.

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Conflict of interest statement

No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. Joinpoint regression analysis by year.
Figure 2.
Figure 2.. Crude mortality rate from 1999–2020 stratified by age.
Figure 3.
Figure 3.
Joinpoint regression analysis by year stratified by 10 year age categories: A. 55–64, B. 65–74, C. 75–84, D. Over 85.
Figure 4.
Figure 4.. Crude mortality rate from 1999–2020 stratified by sex.
Figure 5.
Figure 5.
Joinpoint regression analysis by year stratified by sex: A. Male, B. Female.
Figure 6.
Figure 6.. Crude mortality rate from 1999–2020 stratified by race.
Figure 7.
Figure 7.
Joinpoint regression analysis by year stratified by sex: A. White, B. Black/African American, C. American Indians/Alaska Natives, D. Asians/Pacific Islanders.
See this image and copyright information in PMC

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