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Editorial
. 2024 Dec 31;13(12):3831-3834.
doi: 10.21037/tlcr-24-861. Epub 2024 Dec 24.

Can circulating tumor DNA guide treatment de-escalation in metastatic lung adenocarcinoma harboring actionable genomic alterations?

Affiliations
Editorial

Can circulating tumor DNA guide treatment de-escalation in metastatic lung adenocarcinoma harboring actionable genomic alterations?

Fabian Acker et al. Transl Lung Cancer Res. .
No abstract available

Keywords: Epidermal growth factor receptor (EGFR); circulating tumor DNA (ctDNA); de-escalation; liquid biopsy (LB); non-small cell lung cancer (NSCLC).

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Conflict of interest statement

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://tlcr.amegroups.com/article/view/10.21037/tlcr-24-861/coif). F.A. has received consulting fees from IQVIA, Novartis, and NovoCure, honoraria for presentations from AstraZeneca and Amgen, and support for attending meetings from Daiichi-Sankyo, AstraZeneca, and Amgen. M.S. has received an institutional research grant from AstraZeneca, honoraria for presentations from Novartis, BMS, Boehringer-Ingelheim, Pfizer, Astra-Zeneca, Takeda, Pierre-Fabre, Gilead, Daiichi-Sankyo, and Sanofi, and support for attending meetings from Takeda and Pfizer; and he has participated in data safety monitoring boards for Roche, Boehringer-Ingelheim, AstraZeneca, Sanofi, GSK, and Merck. The authors have no other conflicts of interest to declare.

Comment on

References

    1. Dong S, Wang Z, Zhang JT, et al. Circulating Tumor DNA-Guided De-Escalation Targeted Therapy for Advanced Non-Small Cell Lung Cancer: A Nonrandomized Controlled Trial. JAMA Oncol 2024;10:932-40. 10.1001/jamaoncol.2024.1779 - DOI - PMC - PubMed
    1. Zhang JT, Liu SY, Gao W, et al. Longitudinal Undetectable Molecular Residual Disease Defines Potentially Cured Population in Localized Non-Small Cell Lung Cancer. Cancer Discov 2022;12:1690-701. 10.1158/2159-8290.CD-21-1486 - DOI - PMC - PubMed
    1. Planchard D, Feng PH, Karaseva N, et al. Osimertinib plus platinum-pemetrexed in newly diagnosed epidermal growth factor receptor mutation-positive advanced/metastatic non-small-cell lung cancer: safety run-in results from the FLAURA2 study. ESMO Open 2021;6:100271. 10.1016/j.esmoop.2021.100271 - DOI - PMC - PubMed
    1. Cho BC, Lu S, Felip E, et al. Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC. N Engl J Med 2024;391:1486-98. 10.1056/NEJMoa2403614 - DOI - PubMed
    1. Hochhaus A, Baccarani M, Silver RT, et al. European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia. Leukemia 2020;34:966-84. 10.1038/s41375-020-0776-2 - DOI - PMC - PubMed