Can circulating tumor DNA guide treatment de-escalation in metastatic lung adenocarcinoma harboring actionable genomic alterations?
- PMID: 39830755
- PMCID: PMC11736600
- DOI: 10.21037/tlcr-24-861
Can circulating tumor DNA guide treatment de-escalation in metastatic lung adenocarcinoma harboring actionable genomic alterations?
Keywords: Epidermal growth factor receptor (EGFR); circulating tumor DNA (ctDNA); de-escalation; liquid biopsy (LB); non-small cell lung cancer (NSCLC).
Conflict of interest statement
Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://tlcr.amegroups.com/article/view/10.21037/tlcr-24-861/coif). F.A. has received consulting fees from IQVIA, Novartis, and NovoCure, honoraria for presentations from AstraZeneca and Amgen, and support for attending meetings from Daiichi-Sankyo, AstraZeneca, and Amgen. M.S. has received an institutional research grant from AstraZeneca, honoraria for presentations from Novartis, BMS, Boehringer-Ingelheim, Pfizer, Astra-Zeneca, Takeda, Pierre-Fabre, Gilead, Daiichi-Sankyo, and Sanofi, and support for attending meetings from Takeda and Pfizer; and he has participated in data safety monitoring boards for Roche, Boehringer-Ingelheim, AstraZeneca, Sanofi, GSK, and Merck. The authors have no other conflicts of interest to declare.
Comment on
-
Circulating Tumor DNA-Guided De-Escalation Targeted Therapy for Advanced Non-Small Cell Lung Cancer: A Nonrandomized Controlled Trial.JAMA Oncol. 2024 Jul 1;10(7):932-940. doi: 10.1001/jamaoncol.2024.1779. JAMA Oncol. 2024. PMID: 38869865 Free PMC article. Clinical Trial.
References
-
- Zhang JT, Liu SY, Gao W, et al. Longitudinal Undetectable Molecular Residual Disease Defines Potentially Cured Population in Localized Non-Small Cell Lung Cancer. Cancer Discov 2022;12:1690-701. 10.1158/2159-8290.CD-21-1486 - DOI - PMC - PubMed
-
- Planchard D, Feng PH, Karaseva N, et al. Osimertinib plus platinum-pemetrexed in newly diagnosed epidermal growth factor receptor mutation-positive advanced/metastatic non-small-cell lung cancer: safety run-in results from the FLAURA2 study. ESMO Open 2021;6:100271. 10.1016/j.esmoop.2021.100271 - DOI - PMC - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous