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. 2024 Dec 24;112(1):znae293.
doi: 10.1093/bjs/znae293.

Laparoscopic cholecystectomy versus conservative management for uncomplicated symptomatic gallstones: economic evaluation based on the C-GALL trial

Rodolfo A Hernández  1 , Irfan Ahmed  2 , Karen Edwards  3 , Jemma Hudson  4 , Katie Gillies  4 , Rebecca Bruce  3 , Victoria Bell  3 , Alison Avenell  4 , Jane Blazeby  5 , Miriam Brazzelli  4 , Seonaidh Cotton  3 , Bernard Croal  6 , Graeme MacLennan  3   4 , Peter Murchie  7 , Craig R Ramsay  4
Affiliations

Laparoscopic cholecystectomy versus conservative management for uncomplicated symptomatic gallstones: economic evaluation based on the C-GALL trial

Rodolfo A Hernández et al. Br J Surg. .
No abstract available

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Figures

Fig. 1
Fig. 1
Simplified schematic for the C-GALL Markov model A cohort of individuals with confirmed symptomatic gallstones enter the model in the ‘No surgery’ health state and are assigned to either laparoscopic cholecystectomy or conservative management. Individuals undergoing surgery accrue the cost of the surgical episode and move to the ‘Recovery from surgery’ tunnel state, with an associated reduction in quality of life. On exit from this Markov state, individuals either have their symptoms resolved or not. The absorbing state ‘Death’ can be entered from any other state based on age-specific mortality rates. Individuals receive treatment, as observed in the C-GALL trial, on an intention-to-treat basis, with waiting times being those that occurred in the trial follow-up for the first 24 months. At the start, the mean age was 50.5 years and 71% were women. Monthly Markov cycles and a 10-year time horizon were adopted.
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