Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2025 Apr;210(3):615-625.
doi: 10.1007/s10549-024-07599-x. Epub 2025 Jan 20.

Clinicopathologic characteristics of ductal carcinoma in situ and risk of subsequent invasive breast cancer: a multicenter, population-based cohort study

Thomas E Rohan  1 , Yihong Wang  2 , Fergus Couch  3   4 , Heather Spencer Feigelson  5 , Robert T Greenlee  6 , Stacey Honda  7 , Azadeh Stark  8   9 , Dhananjay Chitale  8   9 , Chenxin Zhang  10 , Xiaonan Xue  10 , Mindy Ginsberg  10 , Olivier Loudig  11
Affiliations
Multicenter Study

Clinicopathologic characteristics of ductal carcinoma in situ and risk of subsequent invasive breast cancer: a multicenter, population-based cohort study

Thomas E Rohan et al. Breast Cancer Res Treat. 2025 Apr.

Abstract

Purpose: To study the association between clinicopathologic characteristics of ductal carcinoma in situ (DCIS) and risk of subsequent invasive breast cancer (IBC).

Methods: We conducted a case-control study nested in a multicenter, population-based cohort of 8175 women aged ≥ 18 years with DCIS diagnosed between 1987 and 2016 and followed for a median duration of 83 months. Cases (n = 497) were women with a first diagnosis of DCIS who developed a subsequent IBC ≥ 6 months later; controls (2/case; n = 959) were matched to cases on age at and calendar year of DCIS diagnosis. Univariable and multivariable conditional logistic regression models were used to examine the associations between the DCIS characteristics of interest (non-screen detection of DCIS, tumor size, positive margins, grade of DCIS, necrosis, architectural pattern, microcalcification, and estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status) and risk of IBC.

Results: In the total study population, the associations were largely null. In subgroup analyses, there were strong position associations with punctate necrosis (pre/perimenopausal women), detection by physical exam (postmenopausal women), architectural patterns other than the main types (breast-conserving surgery [BCS]), and DCIS margins (ipsilateral cases), and inverse associations with HER2 positivity (BCS) and microcalcification (mastectomy); however, the associated confidence intervals were mostly very wide.

Conclusion: The results of this study provide limited support for associations of the DCIS clinicopathologic characteristics studied here and risk of IBC.

Keywords: Clinicopathologic; Ductal carcinoma in situ; Invasive breast cancer; Risk factors.

PubMed Disclaimer

Conflict of interest statement

Declarations. Conflict of interest: The authors have no relevant financial or non-financial interests to disclose. Ethical approval: The study was approved by the Institutional Review Boards of all participating institutions. Consent to participate: In accordance with the OHRP Guidance on Research Involving Coded Private Information or Biological Specimens, this study did not meet the definition of human subject research as defined by 45 CFR 46.102(f), as the data/specimens were not collected specifically for the proposed research project and the data/specimens received did not contain a code derived from individual personal information. Given the foregoing, consent was not required.

References

    1. Hanna WM, Parra-Herran C, Lu FI, Slodkowska E, Rakovitch E, Nofech-Mozes S (2019) Ductal carcinoma in situ of the breast: an update for the pathologist in the era of individualized risk assessment and tailored therapies. Mod Pathol 32(7):896–915. 10.1038/s41379-019-0204-1 - PubMed
    1. Coleman WB (2019) Breast ductal carcinoma in situ: precursor to invasive breast cancer. Am J Pathol 189(5):942–945. 10.1016/j.ajpath.2019.03.002 - PubMed
    1. Morrow M, Katz SJ (2015) Addressing overtreatment in DCIS: what should physicians do now? J Natl Cancer Inst 107(12):djv290. 10.1093/jnci/djv290 - PubMed
    1. Solin LJ, Gray R, Baehner FL, Butler SM, Hughes LL, Yoshizawa C et al (2013) A multigene expression assay to predict local recurrence risk for ductal carcinoma in situ of the breast. J Natl Cancer Inst 105(10):701–710. 10.1093/jnci/djt067 - PMC - PubMed
    1. Dowsett M, Goldhirsch A, Hayes DF, Senn HJ, Wood W, Viale G (2007) International Web-based consultation on priorities for translational breast cancer research. Breast Cancer Res 9(6):R81. 10.1186/bcr1798 - PMC - PubMed

Publication types

MeSH terms