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Case Reports
. 2025 Jan 13:2025:9151514.
doi: 10.1155/crid/9151514. eCollection 2025.

Intraoral Pleomorphic Adenoma of the Minor Salivary Glands: A Case Series of 10 Cases With Emphasis on Histopathological Features

Neetu Jain  1 , Shashi Keshwar  1 , Ashish Shrestha  1 , Mehul Rajesh Jaisani  2 , Iccha Kumar Maharjan  3 , Navin Agrawal  4
Affiliations
Case Reports

Intraoral Pleomorphic Adenoma of the Minor Salivary Glands: A Case Series of 10 Cases With Emphasis on Histopathological Features

Neetu Jain et al. Case Rep Dent. .

Abstract

Pleomorphic adenoma (PA), the most common salivary gland tumor, presents unique challenges due to its diverse clinicopathologic features. The objective of this case series is to highlight the implication of detailed histopathological examination to guide appropriate diagnosis. This study reviews 10 cases of PA diagnosed at B.P. Koirala Institute of Health Sciences, Nepal, between 2011 and 2023. Patients ranged from 16 to 71 years, with a male-to-female ratio of 1:2.3. Most lesions (eight cases) were located on the palate, with additional cases, one on the upper lip and one on the cheek mucosa. Lesion sizes ranged from 1 to 3 cm2 and durations from 2 months to 4 years. Clinically, all lesions were well encapsulated, nontender, and nonulcerated and had normal overlying mucosa. Histopathologically, cases included classical PA, myxoid, and cellular types. Common findings were ductal structures filled with eosinophilic material, a "swarm bee" appearance, plasmacytoid cells, and myxoid stroma. Squamous differentiation and psammoma bodies were observed in some cases. No osseous or cartilaginous components were detected. All cases were excised, with no recurrences reported during at least 2 years of follow-up. Hence, proper diagnosis is crucial for effective management and long-term outcomes of PA.

Keywords: benign mixed tumor; minor salivary glands; pleomorphic adenoma.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Myxoid stroma.
Figure 2
Figure 2
Duct-like structures filled with eosinophilic material in a hyalinized stroma.
Figure 3
Figure 3
Swarm bee appearance.
Figure 4
Figure 4
Cords and strand-like arrangement of cells.
Figure 5
Figure 5
Plasmacytoid cells and mucous cells in a loose fibrillar stroma.
Figure 6
Figure 6
Clear cells lining the ductal structure.
Figure 7
Figure 7
Squamous differentiation and formation of keratin pearl.
Figure 8
Figure 8
Psammoma bodies within the collagenous stroma.
Figure 9
Figure 9
PA resembling schwannoma with numerous spindle cells.
See this image and copyright information in PMC

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