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Review
. 2024 Dec 20;16(12):e76103.
doi: 10.7759/cureus.76103. eCollection 2024 Dec.

Serum Ferritin in Dengue Infection

Yathukulan S  1 , Sundaresan Kt  1
Affiliations
Review

Serum Ferritin in Dengue Infection

Yathukulan S et al. Cureus. .

Abstract

Dengue fever (DF), a significant global health issue, particularly impacts tropical and subtropical regions. Elevated serum ferritin levels are increasingly recognized as a biomarker for severe dengue infection. This review examines the role of serum ferritin in diagnosing and prognosticating dengue severity. It highlights how hyperferritinemia correlates with severe clinical outcomes, including dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). By integrating serum ferritin measurement into routine clinical practice, early identification and intervention for high-risk patients can be enhanced, potentially improving clinical outcomes. Further research should focus on standardizing ferritin level thresholds and exploring the mechanisms underlying ferritin elevation in dengue.

Keywords: biomarker; dengue; hemophagocytic syndrome; hyperferritinemia; prognostic indicator; serum ferritin.

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Conflict of interest statement

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

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