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. 2025 Jun;169(3):891-894.
doi: 10.1002/ijgo.16174. Epub 2025 Jan 21.

Cancer therapy and reproductive impact

Dov Feldberg  1   2 , Nikhil Purandare  3
Affiliations

Cancer therapy and reproductive impact

Dov Feldberg et al. Int J Gynaecol Obstet. 2025 Jun.

Abstract

All patients where the cancer treatment has gonadotoxic potential should be referred for oncofertility advice. The effect of chemotherapy and radiotherapy on the human ovary can vary from no impact to full-blown premature ovarian failure due to hormonal and follicular depletion. Total contraindications to fertility cryopreservation include acute malignancy that requires immediate lifesaving therapy. In prepubertal girls, the only option for urgent fertility preservation is ovarian tissue cryopreservation. Prepubertal testicular tissue cryopreservation is experimental.

Keywords: cancer therapy; chemotherapy and radiotherapy effects; cryopreservation; fertility preservation; gonadotoxicity; oncofertility; ovarian failure; reproductive health.

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Conflict of interest statement

The authors have no conflicts of interest.

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