Transport and inhibition mechanism for human TauT-mediated taurine uptake

Yulin Chao^#¹, Zixuan Zhou^#², Hao Xia^#³, Chuanhui Yang^#¹, Tingting Li^{3

4}, Yi-Quan Tang⁵, Yilai Shu⁶, Qian Ba⁷, Jiaxu Hong^{8

9

10

11}, Dianfan Li^{12

13}, Qianhui Qu¹⁴

Affiliations

¹ Eye & ENT Hospital, Institutes of Biomedical Sciences,Department of Systems Biology for Medicine, Shanghai Key Laboratory of Medical Epigenetics, Fudan University, Shanghai, China.
² Eye & ENT Hospital, Institutes of Biomedical Sciences,Department of Systems Biology for Medicine, Shanghai Key Laboratory of Medical Epigenetics, Fudan University, Shanghai, China. zhouzixuan@fudan.edu.cn.
³ State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecule Cell Science, Chinese Academy of Sciences, Shanghai, China.
⁴ School of Agriculture and Biotechnology, Sun Yat-Sen University, Shenzhen, Guangdong, China.
⁵ State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
⁶ ENT Institute and Otorhinolaryngology Department of the Affiliated Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
⁷ Laboratory Center, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. qba@shsmu.edu.cn.
⁸ Department of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China. jiaxu.hong@fdeent.org.
⁹ NHC Key laboratory of Myopia and Related Eye Diseases, Shanghai, China. jiaxu.hong@fdeent.org.
¹⁰ Shanghai Key Laboratory of Rare Disease Gene Editing and Cell Therapy; Shanghai Engineering Research Center of Synthetic Immunology, Shanghai, China. jiaxu.hong@fdeent.org.
¹¹ Department of Ophthalmology, Children's Hospital of Fudan University, National Pediatric Medical Center of China, Shanghai, China. jiaxu.hong@fdeent.org.
¹² State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecule Cell Science, Chinese Academy of Sciences, Shanghai, China. dianfan.li@sibcb.ac.cn.
¹³ School of Agriculture and Biotechnology, Sun Yat-Sen University, Shenzhen, Guangdong, China. dianfan.li@sibcb.ac.cn.
¹⁴ Eye & ENT Hospital, Institutes of Biomedical Sciences,Department of Systems Biology for Medicine, Shanghai Key Laboratory of Medical Epigenetics, Fudan University, Shanghai, China. qqh@fudan.edu.cn.

^# Contributed equally.

PMID: 39837997
PMCID: PMC12012207 (available on 2026-05-01)
DOI: 10.1038/s41422-025-01076-w

Transport and inhibition mechanism for human TauT-mediated taurine uptake

Yulin Chao et al. Cell Res. 2025 May.

. 2025 May;35(5):381-384.

doi: 10.1038/s41422-025-01076-w. Epub 2025 Jan 21.

Authors

Yulin Chao^#¹, Zixuan Zhou^#², Hao Xia^#³, Chuanhui Yang^#¹, Tingting Li^{3

4}, Yi-Quan Tang⁵, Yilai Shu⁶, Qian Ba⁷, Jiaxu Hong^{8

9

10

11}, Dianfan Li^{12

13}, Qianhui Qu¹⁴

Affiliations

¹ Eye & ENT Hospital, Institutes of Biomedical Sciences,Department of Systems Biology for Medicine, Shanghai Key Laboratory of Medical Epigenetics, Fudan University, Shanghai, China.
² Eye & ENT Hospital, Institutes of Biomedical Sciences,Department of Systems Biology for Medicine, Shanghai Key Laboratory of Medical Epigenetics, Fudan University, Shanghai, China. zhouzixuan@fudan.edu.cn.
³ State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecule Cell Science, Chinese Academy of Sciences, Shanghai, China.
⁴ School of Agriculture and Biotechnology, Sun Yat-Sen University, Shenzhen, Guangdong, China.
⁵ State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
⁶ ENT Institute and Otorhinolaryngology Department of the Affiliated Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
⁷ Laboratory Center, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. qba@shsmu.edu.cn.
⁸ Department of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China. jiaxu.hong@fdeent.org.
⁹ NHC Key laboratory of Myopia and Related Eye Diseases, Shanghai, China. jiaxu.hong@fdeent.org.
¹⁰ Shanghai Key Laboratory of Rare Disease Gene Editing and Cell Therapy; Shanghai Engineering Research Center of Synthetic Immunology, Shanghai, China. jiaxu.hong@fdeent.org.
¹¹ Department of Ophthalmology, Children's Hospital of Fudan University, National Pediatric Medical Center of China, Shanghai, China. jiaxu.hong@fdeent.org.
¹² State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecule Cell Science, Chinese Academy of Sciences, Shanghai, China. dianfan.li@sibcb.ac.cn.
¹³ School of Agriculture and Biotechnology, Sun Yat-Sen University, Shenzhen, Guangdong, China. dianfan.li@sibcb.ac.cn.
¹⁴ Eye & ENT Hospital, Institutes of Biomedical Sciences,Department of Systems Biology for Medicine, Shanghai Key Laboratory of Medical Epigenetics, Fudan University, Shanghai, China. qqh@fudan.edu.cn.

^# Contributed equally.

PMID: 39837997
PMCID: PMC12012207 (available on 2026-05-01)
DOI: 10.1038/s41422-025-01076-w

No abstract available

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Conflict of interest statement

Competing interests: The authors declare no competing interests.

Cited by

Molecular basis for substrate recognition and transport of mammalian taurine transporters.
Wang M, He J, Cai Q, Zhang SA, She J. Wang M, et al. Proc Natl Acad Sci U S A. 2025 Jul 8;122(27):e2425549122. doi: 10.1073/pnas.2425549122. Epub 2025 Jul 2. Proc Natl Acad Sci U S A. 2025. PMID: 40601627

References

1. Singh, P. et al. Science380, eabn9257 (2023). - PMC - PubMed
1. Miyamoto, Y., Tiruppathi, C., Ganapathy, V. & Leibach, F. H. Am. J. Physiol.257, G65–G72 (1989). - PubMed
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1. Preising, M. N. et al. FASEB J.33, 11507–11527 (2019). - PubMed
1. Cao, T. et al. Cell187, 2288–2304.e27 (2024). - PubMed

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Transport and inhibition mechanism for human TauT-mediated taurine uptake

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Transport and inhibition mechanism for human TauT-mediated taurine uptake

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