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Review
. 2025 Apr 1;33(2):102-108.
doi: 10.1097/MOO.0000000000001031. Epub 2025 Jan 22.

When neck lymph nodes metastases do not origin from a head and neck unknown primary

Erim Pamuk  1 , Christian Simon
Affiliations
Review

When neck lymph nodes metastases do not origin from a head and neck unknown primary

Erim Pamuk et al. Curr Opin Otolaryngol Head Neck Surg. .

Abstract

Purpose of review: The evidence for a standardized approach to the management of cervical metastasis from a distant primary tumour is limited. The objective of this review is to provide an overview of the current status of research in this field and to present the latest diagnostic and therapeutic approaches.

Recent findings: Although infraclavicular tumours are typically observed to metastasise to levels IV and V of the neck, all levels may potentially be affected. In conjunction with imaging and immunohistochemical analyses, next-generation sequencing and artificial intelligence-based tools are emerging as potential methods for identifying the primary tumour. Cervical metastasis can be classified as N3 or M1 in accordance with the histology and site of the primary tumour. A neck dissection + adjuvant chemoradiotherapy may prove beneficial in selected patients with breast, nonsmall cell lung, renal cell, oesophageal and testicular cancers, resulting in improved survival rates.

Summary: The diagnosis and subsequent treatment of such cases requires the input of a multidisciplinary team, as the condition is often complex and requires a multifaceted approach. Isolated supraclavicular metastases should prompt the clinician to investigate a distant primary. In select patients with some types of primary tumours, surgical treatment of the neck may improve the prognosis. It is, therefore, essential to control the primary tumour in order to optimize the success of the overall treatment plan.

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Conflict of interest statement

There are no conflicts of interest.

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