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. 2024 Jul 11;3(1):26-39.
doi: 10.1021/envhealth.4c00051. eCollection 2025 Jan 17.

Indoor Environment and Health Effects: Protocol of an Exploratory Panel Study among Young Adults in China (China IEHE Study)

Shan Liu  1 , Wanzhou Wang  1 , Yetong Zhao  1 , Luyi Li  1 , Wenlou Zhang  1 , Xuezhao Ji  1 , Di Yang  1 , Yahong Chen  2 , Xinbiao Guo  1 , Furong Deng  1   3
Affiliations

Indoor Environment and Health Effects: Protocol of an Exploratory Panel Study among Young Adults in China (China IEHE Study)

Shan Liu et al. Environ Health (Wash). .

Abstract

Indoor environment and health have drawn public attention worldwide. However, the joint health effects and mechanisms of exposure to different types of indoor environmental factors remain unclear. We established an exploratory panel study on indoor environment and health effects among young adults in China (the China IEHE Study) to comprehensively investigate 3M issues, including multiple indoor environmental factors, multiple health effects, and multiple omics methods for mechanism exploration. This protocol aims to systematically introduce the entire China IEHE Study. Eighty-one young adults aged 18-28 years from a university adjacent to traffic arteries in Beijing were recruited and followed up four times. Sham/real air purification intervention was simultaneously applied in a randomized crossover order. A broad range of indoor physical, chemical, and biological factors were characterized through real-time monitoring and external and internal exposure analyses. Subclinical health indices reflecting cardiopulmonary, sleep, and cognitive health were repeatedly measured in a prospective order. Various biosamples including fasting venous blood, morning urine, nasal mucosal lining fluid, and exhaled breath condensate were collected to explore the underlying biological mechanisms. The China IEHE Study comes up with an enlightening framework for future prospective studies associated with the exploration of multisystem health effects and underlying biological mechanisms of indoor exposure.

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Conflict of interest statement

The authors declare no competing financial interest.

Figures

Figure 1
Figure 1
Flowchart of the China IEHE Study. EBC, exhaled breath condensate; HEPA, high-efficiency particulate air.
Figure 2
Figure 2
Time schedule of the China IEHE Study. BC, black carbon; CO2, carbon dioxide; EBC, exhaled breath condensate; FeNO, fractional exhaled nitrogen oxide; HRV, heart rate variability; MLF, mucosal lining fluid; NO2, nitrogen dioxide; O3, ozone; PMs, particulate matters; RH, relative humidity; Temp, temperature; TVOCs, total volatile organic compounds.
See this image and copyright information in PMC

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