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Comparative Study
. 1985 Feb-Mar;24(2-3):119-24.
doi: 10.1016/0378-4274(85)90046-3.

Toxicity determined in vitro by morphological alterations and neutral red absorption

E Borenfreund, J A Puerner
Comparative Study

Toxicity determined in vitro by morphological alterations and neutral red absorption

E Borenfreund et al. Toxicol Lett. 1985 Feb-Mar.

Abstract

A method is described which combines the use of a visual morphological cytotoxicity assay with a quantitative neutral red (NR) spectrophotometric test, for the assessment of the effect of toxic agents on 3T3 cells in culture. These sensitive and reproducible assays lend themselves to a screening procedure of potential toxicants which can help reduce the use of animals for toxicity testing.

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