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. 2025 Jan 9:14:54.
doi: 10.12688/f1000research.160088.1. eCollection 2025.

Applications of MR Finger printing derived T1 and T2 values in Adult brain: A Systematic review

Riyan Mohamed Sajer  1 , Saikiran Pendem  1 , Rajagopal Kadavigere  2 , Priyanka -  1 , Shailesh Nayak S  1 , Kaushik Nayak  1 , Tancia Pires  1 , Obhuli Chandran M  1 , Abhijith S  1 , Varsha Raghu  1
Affiliations

Applications of MR Finger printing derived T1 and T2 values in Adult brain: A Systematic review

Riyan Mohamed Sajer et al. F1000Res. .

Abstract

Introduction: Magnetic resonance imaging (MRI) is essential for brain imaging, but conventional methods rely on qualitative contrast, are time-intensive, and prone to variability. Magnetic resonance finger printing (MRF) addresses these limitations by enabling fast, simultaneous mapping of multiple tissue properties like T1, T2. Using dynamic acquisition parameters and a precomputed signal dictionary, MRF provides robust, qualitative maps, improving diagnostic precision and expanding clinical and research applications in brain imaging.

Methods: Database searches were performed through PubMed, Embase, Scopus, Web of science to identify relevant articles focusing on the application of MR finger printing in the adult brain. We utilized the preferred reporting items for systematic reviews and meta-analysis guidelines to extract data from the selected studies.

Results: Nine articles were included in the final review, with a total sample size of 332 participants. In healthy brains, notable regional, sex, age, and hemispheric variations were identified, particularly in the corpus callosum and thalamus. MRF effectively differentiated meningioma subtypes, glioma grades, and IDH mutation status, with T2 values providing particularly predictive for glioma classification. In brain metastases, significant relaxometry differences were noted between normal and lesional tissues. For multiple sclerosis, MRF values correlated with clinical and disability measures, distinguishing relapsing-remitting secondary progressive forms. In traumatic brain injury, longitudinal T1 changes strongly correlated with clinical recovery, surpassing T2 values.

Conclusions: The systematic review highlighted MRD as a groundbreaking technique that enhances neurological diagnosis by simultaneously quantifying T1 and T2 relaxation times. With reduced acquisition times, MRF outperforms conventional MRI in detecting subtle pathologies, distinguishing properties, and providing reliable biomarkers.

Keywords: Brain trauma; Glioma grades; IDH mutation; MR Finger printing; Meningioma; Multiple sclerosis.

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Conflict of interest statement

No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. Flow chart for study selection.
Figure 2.
Figure 2.. Quality assessment of included articles.
See this image and copyright information in PMC

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