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. 2025 Jan 7:15:1529836.
doi: 10.3389/fimmu.2024.1529836. eCollection 2024.

The ancestral architecture of the immune system in simplest animals

Daria Y Romanova  1 , Leonid L Moroz  2   3
Affiliations

The ancestral architecture of the immune system in simplest animals

Daria Y Romanova et al. Front Immunol. .
No abstract available

Keywords: NF-κB; Placozoa; aging; evolution; innate immunity; long-term culturing; trichoplax.

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Conflict of interest statement

All authors declare that the research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Figures

Figure 1
Figure 1
Key immunity components of Placozoa. (A) Multifunctional fiber cells and their intracellular architecture: nucleus, mitochondrial cluster, acidophilic vesicles and bacterial cells as endosymbionts. ER, endoplasmic reticulum; aG, Golgi apparatus. (B) Comparison of 3D protein models for the nuclear factor kappa B between Homo sapiens and Trichoplax adherents in. Colors: green – RHD DNA-binding domain, ultramarine – DEATH domain, wheat color – IPT domain, blue – low complexity region, deep purple – ankyrin domains. NF-kB-like protein in Trichoplax has one extra ankyrin domain, compared to humans, and lacks the canonical DEATH domain.
See this image and copyright information in PMC

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