Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jan 7:15:1488340.
doi: 10.3389/fphar.2024.1488340. eCollection 2024.

Research hotspots and frontiers of endoplasmic reticulum in glomerular podocytes: a bibliometric and visual analysis from 2005 to 2023

Wang Junli  1 , Hao Zhihong  2 , Wang Lina  2 , Ou Qiaoqun  2 , Qu Jing  3 , Hu Jiaqi  2 , Shengyou Yu  1   2   3
Affiliations

Research hotspots and frontiers of endoplasmic reticulum in glomerular podocytes: a bibliometric and visual analysis from 2005 to 2023

Wang Junli et al. Front Pharmacol. .

Abstract

Background: The glomerular podocyte endoplasmic reticulum is a critical component in renal function, yet its research landscape is not fully understood. This study aims to map the existing research on podocyte endoplasmic reticulum by analyzing publications in the Web of Science Core Collection (WOSCC) from the past 19 years.

Methods: We conducted a bibliometric analysis using Citespace, VOSviewer, the Metrology Literature Online platform, and the Bibliometrix software package to visualize and interpret the data from WOSCC. The analysis focused on publication volume, authorship, institutional contributions, and research trends.

Results: The analysis revealed a significant growth in publications, indicating a surge in interest in podocyte endoplasmic reticulum research. Cybulsky, Andrey V, and Papillon, Joan emerge as the most prolific authors, and the Journal of the American Society of Nephrology is the leading journal in this field. China is the top contributor in terms of publications, with McGill University being the most productive institution. The research primarily focuses on endoplasmic reticulum stress, diabetic nephropathy, and apoptosis, with emerging trends in "foot cell apoptosis," "cell signaling pathways," and "autophagy."

Conclusion: The findings highlight the expanding scope of podocyte endoplasmic reticulum research, with a particular emphasis on the mechanisms of endoplasmic reticulum stress and podocyte apoptosis. Future research directions may include the identification of specific therapeutic targets, detailed exploration of podocyte signaling pathways, and the role of autophagy. This study provides a comprehensive overview of the major research areas, frontiers, and trends in podocyte endoplasmic reticulum research, which are pivotal for guiding future investigations.

Keywords: bibliometric analysis; endoplasmic reticulum; endoplasmic reticulum stress; glomerular podocyte; research hotspots.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Structure of GBM and podocyte.
FIGURE 2
FIGURE 2
Flowchart of literature retrieval.
FIGURE 3
FIGURE 3
(A) Change in the number of articles over the years; (B) Change in the number of articles over the years (by country).
FIGURE 4
FIGURE 4
(A) Distribution of the number of articles issued by countries; (B) Analysis of the degree of cooperation and contribution of countries/regions. Note: (A) The darker the color of the country, the higher the number of publications; (B) The larger the area occupying the circle, the higher the number of articles issued; the thicker the line, the stronger the cooperation.
FIGURE 5
FIGURE 5
Author density map.
FIGURE 6
FIGURE 6
Author collaboration map.
FIGURE 7
FIGURE 7
Top 16 references with the strongest citation bursts.
FIGURE 8
FIGURE 8
Keyword clustering graph.
FIGURE 9
FIGURE 9
Keyword time graph.
FIGURE 10
FIGURE 10
(A) Top 17 keywords with the highest citation bursts; (B) A visual dynamic map of the most commonly used keywords.
See this image and copyright information in PMC

References

    1. Almanza A., Carlesso A., Chintha C., Creedican S., Doultsinos D., Leuzzi B., et al. (2018). Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications. FEBS J. 286 (2), 241–278. 10.1111/febs.14608 - DOI - PMC - PubMed
    1. Barutta F., Bellini S., Gruden G. (2022). Mechanisms of podocyte injury and implications for diabetic nephropathy. Clin. Sci. 136 (7), 493–520. 10.1042/cs20210625 - DOI - PMC - PubMed
    1. Cybulsky A. V., Papillon J., Guillemette J., Navarro-Betancourt J. R., Chung C.-F., Iwawaki, et al. (2024). Deletion of IRE1α in podocytes exacerbates diabetic nephropathy in mice. Sci. Rep. 14 (1), 11718. 10.1038/s41598-024-62599-7 - DOI - PMC - PubMed
    1. Fang L., Zhou Y., Cao H., Wen P., Jiang L., He W., et al. (2013). Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia-induced podocyte injury. PLOS ONE 8 (4), e60546. 10.1371/journal.pone.0060546 - DOI - PMC - PubMed
    1. Hara M., Oohara K., Dai D.-F., Liapis H. (2019). Mitotic catastrophe causes podocyte loss in the urine of human diabetics. Am. J. Pathology 189 (2), 248–257. 10.1016/j.ajpath.2018.10.016 - DOI - PMC - PubMed

LinkOut - more resources