Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jan 22.
doi: 10.1007/s11030-025-11109-6. Online ahead of print.

Anti-TMV activity based flavonol derivatives containing piperazine sulfonyl: Design, synthesis and mechanism study

Zhiling Sun  1 , Wei Zeng  1 , Yujiao Qiu  1 , Yuzhi Hu  1 , Qing Zhou  1 , Chunmei Hu  1 , Yuhong Wang  1 , Wei Xue  2
Affiliations

Anti-TMV activity based flavonol derivatives containing piperazine sulfonyl: Design, synthesis and mechanism study

Zhiling Sun et al. Mol Divers. .

Abstract

A series of flavonoid derivatives containing piperazine sulfonate were designed and synthesized. The results of antiviral experiments in vivo showed that some target compounds had good inhibitory effect on tobacco mosaic virus (TMV). The EC50 values of S15 and S19 curative activity were 174.5 and 110.4 μg/mL, respectively, which were better than 253.7 μg/mL of Ningnanmycin (NNM). The EC50 values of S4 and S19 protection activity were 140.3 and 116.1 μg/mL, respectively, better than that of NNM (247.1 μg/mL). Microscale thermophoresis (MST) and molecular docking experiments showed that S19 had a good molecular binding force with TMV. Transmission electron microscopy (TEM) results show that S19 can fracture TMV particles and affect self-assembly. S19 treatment had almost no effect on the growth of seeds and seedlings, and can change the content of chlorophyll malondialdehyde (MDA) and superoxide dismutase (SOD) in tobacco to a certain extent, and improve the disease resistance of tobacco.

Keywords: Anti-TMV; Biosafety; Chlorophyll; Flavonol; Piperazine sulfonate.

PubMed Disclaimer

Conflict of interest statement

Declarations. Conflict of interests: The authors declare no competing interests.

Similar articles

See all similar articles

References

    1. Flood J (2010) The importance of plant health to food security. Food Secur 2:215–231. https://doi.org/10.1007/s12571-010-0072-5 - DOI
    1. Savary S, Willocquet L, Pethybridge SJ, Esker P, McRoberts N, Nelson A (2019) The global burden of pathogens and pests on major food crops. Nat Ecol Evol 3:430–439. https://doi.org/10.1038/s41559-018-0793 - DOI - PubMed
    1. Calil PI, Fontes PEB (2017) Plant immunity against viruses: antiviral immune receptors in focus. Ann Bot 119:711–723. https://doi.org/10.1093/aob/mcw200 - DOI - PubMed
    1. Su CF, Das D, Aslam MM, Xie JQ, Li XY, Chen MX (2023) Eukaryotic splicing machinery in the plant virus battleground. WileyInterdiscip Rev RNA 14:e1793. https://doi.org/10.1002/wrna.1793 - DOI - PubMed
    1. Lefeuvre P, Martin DP, Elena SF, Shepherd DN, Roumagnac P, Varsani A (2019) Evolution and ecology of plant viruses. Nat Rev Microbiol 17:632–644. https://doi.org/10.1038/s41579-019-0232-3 - DOI - PubMed

LinkOut - more resources