Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2025 Jan 17:43:e2024123.
doi: 10.1590/1984-0462/2025/43/2024123. eCollection 2025.

Platelet mass index, systemic immune-inflammation index, and neutrophil-lymphocyte ratio as practical markers in childhood brucellosis

Hilal Koyuncu  1 , Ayşe Tolunay Oflu  1 , Ayşe Güngör  1 , Ayşegül Bükülmez  1
Affiliations
Observational Study

Platelet mass index, systemic immune-inflammation index, and neutrophil-lymphocyte ratio as practical markers in childhood brucellosis

Hilal Koyuncu et al. Rev Paul Pediatr. .

Abstract
in English, Portuguese

Objective: Brucellosis is a multisystem infectious disease and may cause an increase in acute phase reactants. This study aimed to examine the platelet mass index (PMI), the neutrophil-lymphocyte ratio (NLR), and systemic immune-inflammation index (SII) in children with brucellosis and to determine their roles in focal involvement.

Methods: This retrospective observational study included 69 patients with brucellosis and a control group of 69 healthy children. Inflammation markers, PMI, NLR, and SII were compared in brucellosis patients and the control group and in brucellosis patients with and without focal involvement.

Results: Hemoglobin and platelet values were significantly lower in brucellosis cases compared to the control group (p<0.001), and C-reactive protein and ferritin were significantly higher (p<0.001). SII and PMI were significantly lower in the brucellosis patient group compared to the control group (p<0.001). In the comparing cases with and without focal involvement, no statistically significant difference was detected in hematological parameters and inflammation markers.

Conclusions: This study showed that PMI, one of the new markers that can be calculated from complete blood count, may be useful in diagnosing childhood brucellosis. Similar results could not be reached for NLR and SII. New studies testing the diagnostic value of PMI, NLR, and SII in childhood brucellosis are needed.

Objetivo:: A brucelose é uma doença infecciosa multissistêmica e pode causar aumento dos reagentes de fase aguda. Este estudo teve como objetivo examinar o índice de massa plaquetária (PMI, platelet mass index), a relação neutrófilos-linfócitos (NLR, neutrophil-lymphocyte ratio) e o índice de inflamação imunológica sistêmica (SII, systemic immune-inflammation index) em crianças com brucelose, e determinar seus papéis no envolvimento focal.

Métodos:: Este estudo observacional retrospectivo incluiu 69 pacientes com brucelose e um grupo controle de 69 crianças saudáveis. Marcadores de inflamação, PMI, NLR e SII foram comparados em pacientes com brucelose e grupo controle e em pacientes com brucelose com e sem envolvimento focal.

Resultados:: Os valores de hemoglobina e plaquetas foram significativamente menores nos casos de brucelose em comparação ao grupo controle (p<0,001), e proteína C-reativa e ferritina foram significativamente maiores (p<0,001). O SII e o PMI foram significativamente menores no grupo de pacientes com brucelose em comparação ao grupo controle (p<0,001). Na comparação dos casos com e sem envolvimento focal, não foi detectada diferença estatisticamente significativa nos parâmetros hematológicos e marcadores de inflamação.

Conclusões:: Este estudo mostrou que o PMI, um dos novos marcadores que podem ser calculados a partir do hemograma completo, pode ser útil no diagnóstico da brucelose infantil. Resultados semelhantes não puderam ser alcançados para NLR e SII. Novos estudos são necessários para testar o valor diagnóstico de PMI, NLR e SII na brucelose infantil.

PubMed Disclaimer

Conflict of interest statement

Conflict of interests: The authors declare that there is no conflict of interests.

Figures

Figure 1
Figure 1. Receiver operating characteristics curve of platelet mass index and systemic immune-inflammation index to distinguish cases and control groups.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Bukhari EE. Pediatric brucellosis. An update review for the new millennium. Saudi Med J. 2018;39:336–341. doi: 10.15537/smj.2018.4.21896. - DOI - PMC - PubMed
    1. Salvana EM, Salata RA. In: Goldman-Cecil medicine. 25th ed. Goldman L, Schafer AI, editors. Philadelphia: Elsevier; 2015. Brucellosis; pp. 1979–1979.
    1. Downes KJ, Joseph W. St Geme M III, Nathan J, Blum M, editors. Brucella: Nelson texbook of pediatrics. 21st ed. Philadelphia: Elsevier Health Sciences; 2020. pp. 6199–6206.
    1. Afyon M, Artuk C. Could mean platelet volume be a useful marker for infectious diseases? A review of literature. Med Science. 2016;5:1059–1062. doi: 10.5455/medscience.2016.05.8460. - DOI
    1. Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008;454:428–435. doi: 10.1038/nature07201. - DOI - PubMed

Publication types