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. 2025 Apr 8;9(7):1618-1629.
doi: 10.1182/bloodadvances.2024014821.

Anxiety and depression among patients newly diagnosed with lymphoma and myeloma

Oreofe O Odejide  1   2 , Angel M Cronin  1 , Tamryn F Gray  1 , Tsotso Ablorh  3 , Anna Ying  4 , Amelia Yang  3 , Cheyenne Ashley  3 , Anna Tidswell  1 , Eleanor Shi  5 , Miryam Yusufov  6 , Gregory A Abel  1   2 , Lizabeth Roemer  3
Affiliations

Anxiety and depression among patients newly diagnosed with lymphoma and myeloma

Oreofe O Odejide et al. Blood Adv. .

Abstract

Although lymphoma and myeloma confer physical and psychological burden, data are limited regarding anxiety and depression symptoms in affected patients. We conducted a survey between July 2021 and September 2022 to characterize anxiety and depression in a cohort of adult patients, within 6 months of a lymphoma or myeloma diagnosis. Clinically significant anxiety and depression symptoms were defined as scores of ≥8 on the corresponding subscales of the Hospital Anxiety and Depression Scale. We assessed sociodemographic factors associated with anxiety/depression symptoms and examined the relationship between anxiety/depression symptoms and quality of life (QOL) in multivariable analyses. Our cohort included 200 patients (response rate, 74.9%), of whom 45.5% were female, and 55.5% were aged ≥60 years. Over half of the cohort (56.2%) had clinically significant anxiety and/or depression symptoms, with 52.0% (95% confidence interval [CI], 44.9-59.1) meeting the cutoff for anxiety and 27.5% (95% CI, 21.6-34.3) for depression. Lower financial satisfaction (adjusted odds ratio [AOR], 2.43; 95% CI, 1.25-4.78) and greater levels of medical mistrust (AOR, 2.09; 95% CI, 1.10-4.02) were associated with higher odds of anxiety. Lower financial satisfaction (AOR, 2.12; 95% CI, 1.07-4.30) and lower levels of social support (AOR, 2.88; 95% CI, 1.42-6.00) were associated with higher odds of depression. Depression was associated with lower QOL (adjusted mean difference, -22.0; 95% CI, -28.1 to -15.9). More than half of patients newly diagnosed with lymphoma or myeloma experience clinically significant anxiety or depression symptoms, with associated detriment to their QOL. These findings underscore the need for systematic mental health screening and psychological interventions for this population.

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Conflict of interest statement

Conflict-of-interest disclosure: M.Y. consults for One Huddle. O.O.O. has consulted for AstraZeneca. The remaining authors declare no competing financial interests.

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References

    1. Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73(1):17–48. - PubMed
    1. Curran L, Sharpe L, Butow P. Anxiety in the context of cancer: a systematic review and development of an integrated model. Clin Psychol Rev. 2017;56:40–54. - PubMed
    1. Polanski J, Chabowski M, Chudiak A, et al. Intensity of anxiety and depression in patients with lung cancer in relation to quality of life. Adv Exp Med Biol. 2018;1023:29–36. - PubMed
    1. Nguyen MH, Smets EMA, Bol N, et al. Fear and forget: how anxiety impacts information recall in newly diagnosed cancer patients visiting a fast-track clinic. Acta Oncol. 2019;58(2):182–188. - PubMed
    1. Iglay K, Santorelli ML, Hirshfield KM, et al. Diagnosis and treatment delays among elderly breast cancer patients with pre-existing mental illness. Breast Cancer Res Treat. 2017;166(1):267–275. - PubMed

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