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Case Reports
. 2025 Feb:127:110904.
doi: 10.1016/j.ijscr.2025.110904. Epub 2025 Jan 20.

Ocular invasion in sinonasal malignant melanoma: A case report and review of literature

Bijan Khademi  1 , Sajjad Soltani  1 , Alireza Yousefi  1 , Pouya Heidari  1 , Zhale Mardani  2 , Shayan Yousufzai  3
Affiliations
Case Reports

Ocular invasion in sinonasal malignant melanoma: A case report and review of literature

Bijan Khademi et al. Int J Surg Case Rep. 2025 Feb.

Abstract

Background: Sinonasal mucosal melanoma (SNMM) is a rare and aggressive malignancy associated a poor prognosis, prognosis. It is by delayed presentation and nonspecific symptoms. The incidence of SNMM is low, with and there are challenges in achieving local control and managing distant metastases.

Case presentation: We report present case of an 86-year-old female patient with a history of systemic hypertension who presented exhibited symptoms, including blurred vision, rhinorrhea, and facial pain, following initial treatment for SNMM. sinonasal mucosal melanoma (SNMM). studies revealed a heterogeneous lesion in the right nasal cavity and ethmoidal air cells, exhibiting characterized by destruction and invasion into the orbit. The patient underwent functional endoscopic sinus surgery (FESS) for resection, with and analysis confirming confirmed the diagnosis of melanoma.

Discussion: This case underscores the aggressive nature of SNMM and emphasizes importance of early diagnosis and intervention. Despite Although treatment with surgery and radiotherapy leading resulted in resolution for two years, the recurrence of symptoms highlights the challenges in associated with long-term control. The Effective of SNMM requires necessitates multidisciplinary approach, approach that includes resection and the of adjuvant therapies.

Conclusion: SNMM poses presents treatment challenges due to its aggressive behavior nature complex anatomical location. A comprehensive approach involving that includes radiotherapy, and potential systemic therapies is essential for improving enhancing outcomes. Further research is needed necessary explore investigate treatment strategies for this rare malignancy.

Keywords: Adjuvant therapy; Case report; Functional endoscopic sinus surgery; Prognosis; SNMM; Sinonasal mucosal melanoma.

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Conflict of interest statement

Declaration of competing interest The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The coronal view of the PNS CT showing the lesion extending from ethmoidal sinus to the ipsilateral orbit.
Fig. 2
Fig. 2
The coronal view of the PNS MRI confirming the lesion extending from ethmoidal sinus to the ipsilateral orbit.
Fig. 3
Fig. 3
Endoscopic view of the lesion within nasal cavity.
Fig. 4
Fig. 4
Histopathological examination demonstrated polygonal, hyperpigmented nuclei, and spindle cells indicative of malignant melanoma.
See this image and copyright information in PMC

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