[Homocarnosine levels in various regions of the rat brain and blood in hypoxia and after hyperbaric oxygenation]

Abstract

Content of homocarnosine was studied in rat brain departments and blood after hypoxia (9,000 m, 60 min) and hyperoxia (0.3 mPa of oxygen, 60 min) following the hypoxia. In hypoxia content of homocarnosine was unaltered in brain hemispheres and medulla oblongata, it was increased by 41% in midbrain and cerebellum and by 80% in blood. Simultaneous effect of hypoxia and hyperbaric oxygenation decreased the homocarnosine content in brain hemispheres by 22%, in midbrain and diencephalon by 61%, in medulla oblongata by 34%, in cerebellum by 66% and in blood by 39%. Thus, therapeutic doses of hyperbaric oxygenation did not normalize the homocarnosine content in brain of animals with hypoxia.