Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Mar;35(3):183-185.
doi: 10.1016/j.tcb.2025.01.001. Epub 2025 Jan 21.

Splice age: mTORC1-mediated RNA splicing in metabolism and ageing

Pablo Lanuza-Gracia  1 , Jonas Juan-Mateu  2 , Juan Valcárcel  3
Affiliations
Review

Splice age: mTORC1-mediated RNA splicing in metabolism and ageing

Pablo Lanuza-Gracia et al. Trends Cell Biol. 2025 Mar.

Abstract

The target of rapamycin complex mTORC1 has key roles in cell growth and metabolism and its inhibition delays ageing. Recent work by Ogawa et al. in Caenorhabditis elegans argues that modulation of pre-mRNA splicing factors and alternative splicing are key mediators of mTORC1 signalling and can enhance longevity.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests None declared by authors.

Similar articles

See all similar articles

Substances

LinkOut - more resources