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Review
. 2025 Mar;35(3):183-185.
doi: 10.1016/j.tcb.2025.01.001. Epub 2025 Jan 21.

Splice age: mTORC1-mediated RNA splicing in metabolism and ageing

Pablo Lanuza-Gracia  1 , Jonas Juan-Mateu  2 , Juan Valcárcel  3
Affiliations
Review

Splice age: mTORC1-mediated RNA splicing in metabolism and ageing

Pablo Lanuza-Gracia et al. Trends Cell Biol. 2025 Mar.

Abstract

The target of rapamycin complex mTORC1 has key roles in cell growth and metabolism and its inhibition delays ageing. Recent work by Ogawa et al. in Caenorhabditis elegans argues that modulation of pre-mRNA splicing factors and alternative splicing are key mediators of mTORC1 signalling and can enhance longevity.

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Declaration of interests None declared by authors.

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