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. 2025 Jan 22;57(4):676-678.
doi: 10.3724/abbs.2025009.

Head-to-head: IL-21 triumphs over IL-15 in NK cell therapy for glioblastoma

Jake C Miller  1 , Bihui Cao  2 , Jia Shen  2   3   4
Affiliations

Head-to-head: IL-21 triumphs over IL-15 in NK cell therapy for glioblastoma

Jake C Miller et al. Acta Biochim Biophys Sin (Shanghai). .
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

None
Figure 1
Schematic overview of the signal pathway in IL-21 NK cells IL-21 binds to the IL-21 receptor (IL-21R), activating STAT1 and STAT3, which then bind to the CEBPD promoter to drive its expression. CEBPD subsequently activates target genes such as KLF2 and BNIP3L, supporting NK cell survival and enhancing metabolic fitness.
See this image and copyright information in PMC

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