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. 2025 May 1;110(5):1211-1216.
doi: 10.3324/haematol.2024.286886. Epub 2025 Jan 23.

Prevalence and mortality trends of hemoglobinopathies in Italy: a nationwide study

Barbara Gianesin  1 , Frédéric B Piel  2 , Khaled M Musallam  3 , Susanna Barella  4 , Maddalena Casale  5 , Elena Cassinerio  6 , Rosario Di Maggio  7 , Antonia Gigante  1 , Maria Rita Gamberini  8 , Giovanna Graziadei  6 , Roberto Lisi  9 , Filomena Longo  8 , Aurelio Maggio  7 , Raffaella Origa  10 , Annamaria Pasanisi  11 , Silverio Perrotta  5 , Antonio Giulio Piga  12 , Valeria Maria Pinto  13 , Rosamaria Rosso  14 , Giacomo Robello  15 , Giovanna Russo  16 , Marco Zecca  17 , Lucia De Franceschi  18 , Gian Luca Forni  19 , Italian Hemoglobinopathies National Survey Group  20
Affiliations

Prevalence and mortality trends of hemoglobinopathies in Italy: a nationwide study

Barbara Gianesin et al. Haematologica. .

Erratum in

  • Erratum to: Prevalence and mortality trends of hemoglobinopathies in Italy: a nationwide study.
    Gianesin B, Piel FB, Musallam KM, Barella S, Casale M, Cassinerio E, Di Maggio R, Gigante A, Gamberini MR, Graziadei G, Lisi R, Longo F, Maggio A, Origa R, Pasanisi A, Perrotta S, Piga AG, Pinto VM, Rosso R, Robello G, Russo G, Zecca M, De Franceschi L, Forni GL. Gianesin B, et al. Haematologica. 2025 Jun 1;110(6):1449-1450. doi: 10.3324/haematol.2025.287581. Epub 2025 Jun 1. Haematologica. 2025. PMID: 40458940 Free PMC article. No abstract available.
No abstract available

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Figures

Figure 1.
Figure 1.
Hemoglobinopathies in Italy according to the national survey in 2019. (A) Geographical distribution of facilities included in the survey (N=131); black points indicate the location of the 8 reference centers included in the survival cohort analyses. The administrative units shown are the 20 regions (administrative level 1) of Italy. (B) Distribution of patients per 100,000 inhabitants by region in Italy. (C) Distribution of patients by age and sex for transfusion-dependent thalassemia (TDT), non-transfusion-dependent thalassemia (NTDT), and sickle cell disease (SCD) patients, with light gray bars reflecting age distribution of the general Italian population in 2019.
Figure 2.
Figure 2.
Kaplan-Meier survival curves for the survival cohort with comparisons by hemoglobinopathy type and sex. (A) Survival comparisons for transfusion-dependent thalassemia (TDT), non-transfusion-dependent thalassemia (NTDT), and sickle cell disease (SCD). (B) Survival in TDT females and males. (C) Survival in NTDT females and males. (D) Survival in SCD females and males.
See this image and copyright information in PMC

References

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