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Review
. 2025 Jan 7:15:1465373.
doi: 10.3389/fmicb.2024.1465373. eCollection 2024.

Regulatory mechanisms and applications of Lactobacillus biofilms in the food industry

Peilin Yao  1   2 , Effarizah Mohd Esah  1 , Chuanping Zhao  2
Affiliations
Review

Regulatory mechanisms and applications of Lactobacillus biofilms in the food industry

Peilin Yao et al. Front Microbiol. .

Abstract

Lactobacillus is widely recognized for its probiotic benefits and has been widely used in food production. While biofilms are typically associated with pathogenic bacteria, they also served as a self-protective mechanism formed by microorganisms in an adverse environments. In recent years, relevant studies have revealed the excellent characteristics of Lactobacillus biofilms, offering new insights into their potential applications in the food industry. The Lactobacillus biofilms is important in improving fermentation processes and enhancing the resilience of Lactobacillus in various conditions. This paper reviews how quorum sensing regulates the formation of Lactobacillus biofilms and explores their roles in stress resistance, bacteriostasis and food production. Additionally, it highlights the emerging concept of fourth-generation probiotics, developed through biofilm technology, as a novel approach to probiotic applications.

Keywords: Lactobacillus; biofilm; encapsulation; quorum sensing; stress resistance.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Formation and regulation of lactic acid bacteria biofilms.
See this image and copyright information in PMC

References

    1. Akoglu A. (2020). The effect of some environmental conditions on planktonic growth and biofilm formation by some lactic acid bacteria isolated from a local cheese in Turkey. Biotechnol. Lett. 42 481–492. 10.1007/s10529-020-02794-4 - DOI - PubMed
    1. Al Azzaz J., Al Tarraf A., Heumann A., Barreira D. D., Laurent J., Assifaoui A., et al. (2020). Resveratrol favors adhesion and biofilm formation of Lacticaseibacillus paracasei subsp. paracasei strain ATCC334. Int. J. Mol. Sci. 21:5423. 10.3390/ijms21155423 - DOI - PMC - PubMed
    1. Al-Hadidi A., Navarro J., Goodman S. D., Bailey M. T., Besner G. E. (2021). Lactobacillus reuteri in its biofilm state improves protection from experimental necrotizing enterocolitis. Nutrients 13:918. 10.3390/nu13030918 - DOI - PMC - PubMed
    1. Allison D. G. (2003). The biofilm matrix. Biofouling 19 139–150. 10.1080/0892701031000072190 - DOI - PubMed
    1. Assaf J. C., El Khoury A., Chokr A., Louka N., Atoui A. (2019). A novel method for elimination of aflatoxin M1 in milk using Lactobacillus rhamnosus GG biofilm. Int. J. Dairy Technol. 72 248–256. 10.1111/1471-0307.12578 - DOI

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