Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jan 8:14:1465987.
doi: 10.3389/fonc.2024.1465987. eCollection 2024.

Nanoparticles in gynecologic cancers: a bibliometric and visualization analysis

Yunzhe Zhou  1 , Lizhang Chen  1 , Tingting Wang  1
Affiliations

Nanoparticles in gynecologic cancers: a bibliometric and visualization analysis

Yunzhe Zhou et al. Front Oncol. .

Abstract

Background: Gynecological cancers are characterized by uncontrolled cell proliferation within the female reproductive organs. These cancers pose a significant threat to women's health, impacting life expectancy, quality of life, and fertility. Nanoparticles, with their small size, large surface area, and high permeability, have become a key focus in targeted cancer therapy. The aim of this study is to review recent advancements in nanoparticles applied to gynecologic cancers, providing valuable insights for future research.

Methods: We retrieved all literature on nanoparticles in gynecologic cancers from the Web of Science Core Collection (WOSCC) database between January 1, 2004, and June 4, 2024. Data analysis and visualization were conducted using R software (version 4.4.0), VOSviewer (version 1.6.19.0), and CiteSpace (version 6.1).

Results: A total of 2,843 publications from January 1, 2004, to June 4, 2024 were searched. Over the past 20 years, there has been a significant increase in publications. The leading countries and institutions in terms of productivity are China and the Chinese Academy of Sciences. The most prolific author and the most co-cited author are Sood, A K and Siegel, Rl. The top journals are the International Journal of Nanomedicine (n=97), followed by ACS Applied Materials & Interfaces (n=72) and Journal of Materials Chemistry B (n=53). Keyword analysis shows current research focuses on two main areas: the application of nanoparticles for drug delivery and their broader applications in gynecologic cancers. Future research will likely focus on "silver nanoparticles," "gold nanoparticles," and "green synthesis."

Conclusions: Over the past two decades, nanoparticles have rapidly advanced in the field of gynecologic cancers. Research has primarily focused on the applications of nanoparticles in drug delivery and applications. Future trends point toward optimizing synthesis techniques and advancing preclinical studies to clinical applications, particularly for silver and gold nanoparticles. These findings provide valuable scientific insights for researchers.

Keywords: bibliometric analysis; gynecologic cancers; nanomaterials; nanoparticles; visualization analysis.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the publications selection.
Figure 2
Figure 2
The number of publications and citations.
Figure 3
Figure 3
Visual map of countries/regions and institutions: (A) Geographic distribution map based on publication counts (B) Collaboration network visualization for countries/regions (C) Institutions with 10 or more publications.
Figure 4
Figure 4
The dual-map overlay of journals in the field of nanoparticles in gynecologic cancers.
Figure 5
Figure 5
The network visualization map of authors: (A) Visualization analysis graph of author collaboration network; (B) The network visualization map of co-cited authors.
Figure 6
Figure 6
The network visualization map of references: (A) Co-citation network of references with 20 or more citations. (B) Density visualization of references co-cited 20 times or more.
Figure 7
Figure 7
The network visualization map of keywords in the field of nanoparticles in gynecologic cancers: (A) Network visualization of keywords appearing 10 times or more. (B) Overlay visualization of keywords appearing 10 times or more. (C) Development trend and importance of hot spots.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. CDC . Gynecologic Cancers Basics, in: Gynecologic cancers (2024). Available online at: https://www.cdc.gov/gynecologic-cancer/about/index.html (Accessed June 11, 2024).
    1. Casey C, Chen LM, Rabow MW. Symptom management in gynecologic Malignancies. Expert Rev Anticancer Ther. (2011) 11:1077–89. doi: 10.1586/era.11.83 - DOI - PubMed
    1. Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. (2024) 74:12–49. doi: 10.3322/caac.21820 - DOI - PubMed
    1. Suneja G, Viswanathan A. Gynecologic Malignancies. Hematol Oncol Clin North Am. (2020) 34:71–89. doi: 10.1016/j.hoc.2019.08.018 - DOI - PubMed
    1. Yun BS, Park EH, Ha J, Lee JY, Lee KH, Lee TS, et al. . Incidence and survival of gynecologic cancer including cervical, uterine, ovarian, vaginal, vulvar cancer and gestational trophoblastic neoplasia in Korea, 1999–2019: Korea Central Cancer Registry. Obstet Gynecol Sci. (2023) 66:545–61. doi: 10.5468/ogs.23208 - DOI - PMC - PubMed

Publication types

LinkOut - more resources